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Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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ABO

Homo sapiens · Histo-blood group ABO system transferase (EC 2.4.1.40; 2.4.1.37)

GT6Model organism · annotation ≥ 4Fold GT-ARetaining151 PDB structure(s)

External resources

UniProt P16442AlphaFold modelInterPro domainsNCBI Gene 28CAZy GT6PDB 1LZ0PDB 1LZ7PDB 1LZIPDB 1LZJPDB 1R7TPDB 1R7UPDB 1R7VPDB 1R7X

Identification and annotation

CAZy familyGT6 · CAZy entry
Gene symbolABO
Synonyms / alternate names
  • Fucosylglycoprotein 3-alpha-galactosyltransferase
  • Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
  • Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
  • Glycoprotein-fucosylgalactoside alpha-galactosyltransferase
  • Histo-blood group A transferase
  • Histo-blood group B transferase
  • NAGAT
UniProt accessionP16442
NCBI Gene ID28
Source speciesHomo sapiens
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme functionHisto-blood group ABO system transferase (EC 2.4.1.40; 2.4.1.37)
Subcellular location
  • Golgi apparatus, Golgi stack membrane
  • Secreted

Structure and mechanism

Fold typeGT-A
Catalytic mechanismRetaining
Cation dependenceYes (Mn2+)
Oligomeric statenot curated
PDB structures1LZ0, 1LZ7, 1LZI, 1LZJ, 1R7T, 1R7U, 1R7V, 1R7X, 1R7Y, 1R80, 1R81, 1R82, 1WSZ, 1WT0, 1WT1, 1WT2, 1WT3, 1XZ6, 1ZHJ, 1ZI1, 1ZI3, 1ZI4, 1ZI5, 1ZIZ, 1ZJ0, 1ZJ1, 1ZJ2, 1ZJ3, 1ZJO, 1ZJP, 2A8U, 2A8W, 2I7B, 2O1F, 2O1G, 2O1H, 2PGV, 2PGY, 2RIT, 2RIX, 2RIY, 2RIZ, 2RJ0, 2RJ1, 2RJ4, 2RJ5, 2RJ6, 2RJ7, 2RJ8, 2RJ9, 2Y7A, 3I0C, 3I0D, 3I0E, 3I0F, 3I0G, 3I0H, 3I0I, 3I0J, 3I0K, 3I0L, 3IOH, 3IOI, 3IOJ, 3SX3, 3SX5, 3SX7, 3SX8, 3SXA, 3SXB, 3SXC, 3SXD, 3SXE, 3SXG, 3U0X, 3U0Y, 3V0L, 3V0M, 3V0N, 3V0O, 3V0P, 3V0Q, 3ZGF, 3ZGG, 4C2S, 4FQW, 4FRA, 4FRB, 4FRD, 4FRE, 4FRH, 4FRL, 4FRM, 4FRO, 4FRP, 4FRQ, 4GBP, 4KC1, 4KC2, 4KC4, 4KXO, 4Y62, 4Y63, 4Y64, 5BXC, 5C1G, 5C1H, 5C1L, 5C36, 5C38, 5C3A, 5C3B, 5C3D, 5C47, 5C48, 5C49, 5C4B, 5C4C, 5C4D, 5C4E, 5C4F, 5C8R, 5CMF, 5CMG, 5CMH, 5CMI, 5CMJ, 5CQL, 5CQM, 5CQN, 5CQO, 5CQP, 5M79, 5M7A, 5M7B, 5M7C, 5M7D, 5TJK, 5TJL, 5TJN, 5TJO, 6BJI, 6BJJ, 6BJK, 6BJL, 6BJM, 6GWY, 6GWZ, 6GX0, 6GX1, 6GX2

Donor and acceptor specificity

Sugar nucleotide donor
  • UDP-N-acetyl-alpha-D-galactosamine
  • UDP-alpha-D-galactose
Donor CCD code(s)UD2, GDU
Acceptor substrate(s)
  • an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative
  • an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative
  • an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative
  • an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc derivative
  • an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GalNAc derivative
  • an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-Glc derivative
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

354 aa 
MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP

Catalytic domain sequence

279 aa 
SLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTA
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