Home/GT Families/GT6/Abo2
Abo2
Rattus norvegicus · Histo-blood group ABO system transferase 2 (EC 2.4.1.40; 2.4.1.37)
GT6Non-model organism · annotation 4–5Fold GT-ARetaining
External resources
Identification and annotation
| CAZy family | GT6 · CAZy entry |
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| Gene symbol | Abo2 |
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| Synonyms / alternate names | - B blood group galactosyltransferase
- Blood group A glycosyltransferase 2
- Cis-AB transferase 2
- Fucosylglycoprotein 3-alpha-galactosyltransferase
- Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
- Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
- Glycoprotein-fucosylgalactoside alpha-galactosyltransferase
- Histo-blood group A transferase
- Histo-blood group B transferase
- NAGAT 2
- Putative blood group A transferase T2
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| UniProt accession | Q8CFC4 |
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| NCBI Gene ID | 100301568 |
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| Source species | Rattus norvegicus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Histo-blood group ABO system transferase 2 (EC 2.4.1.40; 2.4.1.37) |
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| Subcellular location | - Golgi apparatus, Golgi stack membrane
- Secreted
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-N-acetyl-alpha-D-galactosamine
- UDP-alpha-D-galactose
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| Donor CCD code(s) | UD2, GDU |
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| Acceptor substrate(s) | an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
334 aa
MKDLRFGRLKCYSLHLGILPLTVLVLVFFCFVCLSLRSQEWGHPGAVNRKAYPQPRVLTPTRTDVLVLTPWLAPIIWEGTFDIDTLNEQFRLRNTTIGLTVFAVKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVPLGAGRRLVVLTVRNYTRWQDVSMHRMEVISHFSEQRFRHEVDYLVCADVDMKFRDHVGVEILSALFGTLHPGFYRSRRESFTYERRPQSQAYIPWDQGDFYYMGAFFGGSVVEVHHLTKACHQAMVEDQANGIEAVWHDESHLNKYLLYHKPTKVLSPEYMWDQQLLGWPSIMKKLRYVAVPKNHQAIRN
Catalytic domain sequence
289 aa
AVNRKAYPQPRVLTPTRTDVLVLTPWLAPIIWEGTFDIDTLNEQFRLRNTTIGLTVFAVKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVPLGAGRRLVVLTVRNYTRWQDVSMHRMEVISHFSEQRFRHEVDYLVCADVDMKFRDHVGVEILSALFGTLHPGFYRSRRESFTYERRPQSQAYIPWDQGDFYYMGAFFGGSVVEVHHLTKACHQAMVEDQANGIEAVWHDESHLNKYLLYHKPTKVLSPEYMWDQQLLGWPSIMKKLRYVAVPKNHQAIRN
