Home/GT Families/GT61/POMGNT2
POMGNT2
Homo sapiens · Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (EC 2.4.1.312)
GT61Model organism · annotation ≥ 4Fold GT-BInverting3 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT61 · CAZy entry |
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| Gene symbol | POMGNT2 |
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| Synonyms / alternate names | - AGO61
- C3orf39
- EOGTL
- GTDC2
- Extracellular O-linked N-acetylglucosamine transferase-like
- Glycosyltransferase-like domain-containing protein 2
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| UniProt accession | Q8NAT1 |
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| NCBI Gene ID | 84892 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (EC 2.4.1.312) |
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| Subcellular location | Endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | 6XFI, 6XI2, 8KB7 |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
580 aa
MHLSAVFNALLVSVLAAVLWKHVRLREHAATLEEELALSRQATEPAPALRIDYPKALQILMEGGTHMVCTGRTHTDRICRFKWLCYSNEAEEFIFFHGNTSVMLPNLGSRRFQPALLDLSTVEDHNTQYFNFVELPAAALRFMPKPVFVPDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAHEARLFFMEGWGEGAHFDLYKLLSPKQPLLRAQLKTLGRLLCFSHAFVGLSKITTWYQYGFVQPQGPKANILVSGNEIRQFARFMTEKLNVSHTGVPLGEEYILVFSRTQNRLILNEAELLLALAQEFQMKTVTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVVELFPYAVNPDHYTPYKTLAMLPGMDLQYVAWRNMMPENTVTHPERPWDQGGITHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTKVDIPSLIQTIRRVVKGRPGPRKQKWTVGLYPGKVREARCQASVHGASEARLTVSWQIPWNLKYLKVREVKYEVWLQEQGENTYVPYILALQNHTFTENIKPFTTYLVWVRCIFNKILLGPFADVLVCNT
Catalytic domain sequence
104 aa
VSGNEIRQFARFMTEKLNVSHTGVPLGEEYILVFSRTQNRLILNEAELLLALAQEFQMKTVTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVV
