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botv
Drosophila melanogaster · Exostosin-3 (EC 2.4.1.223)
GT64Model organism · annotation ≥ 4Fold GT-ARetaining
External resources
Identification and annotation
| CAZy family | GT64 · CAZy entry |
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| Gene symbol | botv |
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| Synonyms / alternate names | - DEXT3
- Protein brother of tout-velu
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| UniProt accession | Q9XZ08 |
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| NCBI Gene ID | 37198 |
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| Source species | Drosophila melanogaster |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Exostosin-3 (EC 2.4.1.223) |
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| Subcellular location | - Endoplasmic reticulum membrane
- Golgi apparatus membrane
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | Interacts with sau |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
972 aa
MPPAYDLGHSGEAYQPLDTGSGGGNEACAPNSSSAQIRHSMGFRTSWMRQFRRYKLPMVLLMLLFLVSCLAYRILSVEQDAPPLDLHRSSPLLDAYEDFSAMRAGDLKMRIEEMVRIKSTVSVELRELESRRQKLQSDISQYNQKIEELKQELLREQTELERLKISVEQAQVAQREAVQRNTPDLALPRSLLPNTLPRKSNPITGGMAASCEMHNCFNHSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTLGYNAHIVKDPKHACIYLVLVGEALLEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEKLYSLPYWGGDGRNHVLLNLARRDLTSHRTNPLYRQNTMRAIVVQSAFEREQFRPGYDLIVPPILGPPGGDVWQECAEMVPARRKYLLTYQGELRPKQSSLNPLDAFILEHLADMAKGATQDQFVLQFQCVPATEQQEGDSLPDWTLCGSDSSRRQLLKDSTFSLILPPLNGRVSSTLMLARIYEALRSGAVPVILGADELRLPYAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQATVDTVIASLRDRLGIPPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEESLGPIEPPYPSPAFRRNYTILRMQAKEAWNDWLDPFYLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGKEFGESLGGNYPREQFTIVMLTYEREQVLMDSLGRLYGLPYLHKVVVVWNSPKPPLDDLRWPDIGVPVAVLRAPRNSLNNRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYHAWDLGNPNGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNFLVSHITRKPPVKVTSRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADSILFKTRIPHDKQKCFKYI
Catalytic domain sequence
326 aa
TSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTLGYNAHIVKDPKHACIYLVLVGEALLEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEKLYSLPYWGGDGRNHVLLNLARRDLTSHRTNPLYRQNTMRAIVVQSAFEREQFRPGYDLIVPPILGPPGGDVWQECAEMVPARRKYLLTYQGELRPKQSSLNPLDAFILEHLADMAKGATQDQFVLQFQCVPATEQQEGDSLPDWTLCGSDSSRRQLLKDSTFSLILPPLNGRVSSTLMLARIYEALRSGAVPVILGADELRLPYAETVDWRRTALLLPKARITELHFLLRA
