Home/GT Families/GT65/Pofut1
Pofut1
Rattus norvegicus · GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221)
GT65Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT65 · CAZy entry |
|---|
| Gene symbol | Pofut1 |
|---|
| Synonyms / alternate names | - Fut12
- Peptide-O-fucosyltransferase 1
|
|---|
| UniProt accession | Q6EV70 |
|---|
| NCBI Gene ID | 311551 |
|---|
| Source species | Rattus norvegicus |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) |
|---|
| Subcellular location | Endoplasmic reticulum |
|---|
Structure and mechanism
| Fold type | GT-B |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
|---|
| Donor CCD code(s) | GFB |
|---|
| Acceptor substrate(s) | - L-seryl-[protein]
- L-threonyl-[protein]
|
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
395 aa
MGAAAWAPSHLLLRASFLLLLLLLPLPLRGRAGGSWDLAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRVISLEDFMEKLAPFHWPPEKRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYKEQWIQRFPPKEHPVLALPGAPAQFPVLEEHRELQKYMVWSDEMVRTGEAQISTHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTATPLTTTMCLPDLKEIQRAVKLWVRALDARSVYIATDSESYVSEIQQLFKEKVKVVSLKPEVAQIDLYILGQADHFIGNCVSSFTAFVKRERDLHGRPSSFFGMDRPSQLRDEF
Catalytic domain sequence
350 aa
DLAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRVISLEDFMEKLAPFHWPPEKRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYKEQWIQRFPPKEHPVLALPGAPAQFPVLEEHRELQKYMVWSDEMVRTGEAQISTHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTATPLTTTMCLPDLKEIQRAVKLWVRALDARSVYIATDSESYVSEIQQLFKEKVKVVSLKPEVAQIDLYILGQADHFIGNCVSSFTAFVKRERDLHGRPSSFFGMD
