Home/GT Families/GT68/POFUT2
POFUT2
Homo sapiens · GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221)
GT68Model organism · annotation ≥ 4Fold GT-BInverting2 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT68 · CAZy entry |
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| Gene symbol | POFUT2 |
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| Synonyms / alternate names | - C21orf80
- FUT13
- KIAA0958
- Peptide-O-fucosyltransferase 2
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| UniProt accession | Q9Y2G5 |
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| NCBI Gene ID | 23275 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) |
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| Subcellular location | - Endoplasmic reticulum
- Golgi apparatus
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | 4AP5, 4AP6 |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | - L-seryl-[protein]
- L-threonyl-[protein]
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
429 aa
MATLSFVFLLLGAVSWPPASASGQEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRRDVYIRIASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVLQSYAEGWKEGTWEEKVDERPCIDQLLYSQDKHEYYRGWFWGYEETRGLNVSCLSVQGSASIVAPLLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSMVFARHLREVGDEFRSRHLNSTDDADRIPFQEDWMKMKVKLGSALGGPYLGVHLRRKDFIWGHRQDVPSLEGAVRKIRSLMKTHRLDKVFVATDAVRKEYEELKKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKITY
Catalytic domain sequence
370 aa
YLLYDVNPPEGFNLRRDVYIRIASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVLQSYAEGWKEGTWEEKVDERPCIDQLLYSQDKHEYYRGWFWGYEETRGLNVSCLSVQGSASIVAPLLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSMVFARHLREVGDEFRSRHLNSTDDADRIPFQEDWMKMKVKLGSALGGPYLGVHLRRKDFIWGHRQDVPSLEGAVRKIRSLMKTHRLDKVFVATDAVRKEYEELKKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGD
