Home/GT Families/GT7/B4GALT5
B4GALT5
Homo sapiens · Beta-1,4-galactosyltransferase 5 (EC 2.4.1.-; 2.4.1.274)
GT7Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT7 · CAZy entry |
|---|
| Gene symbol | B4GALT5 |
|---|
| Synonyms / alternate names | - Beta-1,4-GalT II
- Glucosylceramide beta-1,4-galactosyltransferase
- Lactosylceramide synthase
- UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5
- UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5
|
|---|
| UniProt accession | O43286 |
|---|
| NCBI Gene ID | 9334 |
|---|
| Source species | Homo sapiens |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | Beta-1,4-galactosyltransferase 5 (EC 2.4.1.-; 2.4.1.274) |
|---|
| Subcellular location | - Golgi apparatus, Golgi stack membrane
- Golgi apparatus
|
|---|
Structure and mechanism
| Fold type | GT-A |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | Yes (Mn2+) |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
|---|
| Donor CCD code(s) | GDU |
|---|
| Acceptor substrate(s) | a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine |
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
388 aa
MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLFMMQAQGILIRDNVRTIGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKLGGHWKPSDCMPRWKVAILIPFRNRHEHLPVLFRHLLPMLQRQRLQFAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALLRKSKERQGLDGLNNLNYFANITYDALYKNITVNLTPELAQVNEY
Catalytic domain sequence
217 aa
RWKVAILIPFRNRHEHLPVLFRHLLPMLQRQRLQFAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALLRKSKERQGLDGLNNLNYFANITYDALYKNITVN
