B4GALT7 (GT7)

B4GALT7

Homo sapiens · Beta-1,4-galactosyltransferase 7 (EC 2.4.1.-; 2.4.1.133)

GT7Model organism · annotation ≥ 4Fold GT-AInverting2 PDB structure(s)

External resources

UniProt Q9UBV7 AlphaFold model InterPro domains NCBI Gene 11285 CAZy GT7 PDB 4IRP PDB 4IRQ

Identification and annotation

CAZy family	GT7 · CAZy entry
Gene symbol	B4GALT7
Synonyms / alternate names	XGALT1 Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7 UDP-galactose:beta-xylose beta-1,4-galactosyltransferase XGPT XGalT-1 Xylosylprotein 4-beta-galactosyltransferase Xylosylprotein beta-1,4-galactosyltransferase
UniProt accession	`Q9UBV7`
NCBI Gene ID	`11285`
Source species	Homo sapiens
Taxonomic domain	Eukaryota
UniProt annotation level	5

Function and localisation

Enzyme function	Beta-1,4-galactosyltransferase 7 (EC 2.4.1.-; 2.4.1.133)
Subcellular location	Golgi apparatus Golgi stack membrane

Structure and mechanism

Fold type	GT-A
Catalytic mechanism	Inverting
Cation dependence	Yes (Mn2+)
Oligomeric state	not curated
PDB structures	`4IRP`, `4IRQ`

Donor and acceptor specificity

Sugar nucleotide donor	UDP-alpha-D-galactose
Donor CCD code(s)	`GDU`
Acceptor substrate(s)	3-O-(beta-D-xylosyl)-L-seryl-[protein]
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

327 aa

MFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPPPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS

Catalytic domain sequence

224 aa

PHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDREGGLNTVKYHVASRTALSVGGAPCTVLNIMLD