Home/GT Families/GT8/Xxylt1
Xxylt1
Mus musculus · Xyloside xylosyltransferase 1 (EC 2.4.2.62)
GT8Non-model organism · annotation 4–5Fold GT-ARetaining10 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT8 · CAZy entry |
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| Gene symbol | Xxylt1 |
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| Synonyms / alternate names | - UDP-xylose:alpha-xyloside alpha-1
- 3-xylosyltransferase
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| UniProt accession | Q3U4G3 |
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| NCBI Gene ID | 268880 |
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| Source species | Mus musculus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Xyloside xylosyltransferase 1 (EC 2.4.2.62) |
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| Subcellular location | Endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mg2+, Mn2+) |
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| Oligomeric state | homodimer |
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| PDB structures | 4WLG, 4WLM, 4WLZ, 4WM0, 4WMA, 4WMB, 4WMI, 4WMK, 4WN2, 4WNH |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-xylose |
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| Donor CCD code(s) | UDX |
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| Acceptor substrate(s) | 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
392 aa
MGLLRGGAACARAMARLGALRSHYCALLLAAALAVCAFYYLGSGRETFSSATKRLKEARAGAAAPTPPAPELARGSAAPASGAKAKSLEGGVVVPVDYHLLMMFTKAEHNAPLQAKARVALSSLLRLAKFEAHEVLNLHFVSEEASREVAKALLRELLPPAAGFKCKVIFHDVAVLTDKLFPVVEAMQKYFSAGSGTYYSDSIFFLSVAMHQIMPKEIPRIIQLDLDLKYKTNIRELFEEFDNFLPGAVIGIAREMQPVYRHTFWQFRHENPKTRVGDPPPEGLPGFNSGVMLLNLEAMRQSPLYSHLLEPSWVQQLADKYHFRGHLGDQDFFTMIGMEHPELFHVLDCTWNRQLCTWWRDHGYSDVFQAYFRCEGHVKIYHGNCNTPIPED
Catalytic domain sequence
174 aa
FPVVEAMQKYFSAGSGTYYSDSIFFLSVAMHQIMPKEIPRIIQLDLDLKYKTNIRELFEEFDNFLPGAVIGIAREMQPVYRHTFWQFRHENPKTRVGDPPPEGLPGFNSGVMLLNLEAMRQSPLYSHLLEPSWVQQLADKYHFRGHLGDQDFFTMIGMEHPELFHVLDCTWNRQ
