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waaC
Escherichia coli O18:K1:H7 (strain RS218 / NMEC) · Lipopolysaccharide heptosyltransferase 1 (EC 2.4.99.23)
GT9Model organism · annotation ≥ 4Fold GT-BInverting3 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT9 · CAZy entry |
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| Gene symbol | waaC |
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| Synonyms / alternate names | ADP-heptose:lipopolysaccharide heptosyltransferase I |
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| UniProt accession | P0DX54 |
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| NCBI Gene ID | not curated |
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| Source species | Escherichia coli O18:K1:H7 (strain RS218 / NMEC) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Lipopolysaccharide heptosyltransferase 1 (EC 2.4.99.23) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | monomer |
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| PDB structures | 2GT1, 2H1F, 2H1H |
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Donor and acceptor specificity
| Sugar nucleotide donor | ADP-L-glycero-beta-D-manno-heptose |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | - an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A
- alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
326 aa
MRVLIVKTSSMGDVLHTLPALTDAQQAIPGIKFDWVVEEGFAQIPSWHAAVERVIPVAIRRWRKAWFSAPIKAERKAFREALQAKNYDAVIDAQGLVKSAALVTRLAHGVKHGMDWQTAREPLASLFYNRKHHIAKQQHAVERTRELFAKSLGYSKPQTQGDYAIAQHFLTNLPTDAGEYAVFLHATTRDDKHWPEEHWRELIGLLADSGIRIKLPWGAPHEEERAKRLAEGFAYVEVLPKMSLEGVARVLAGAKFVVSVDTGLSHLTAALDRPNITVYGPTDPGLIGGYGKNQMVCRAPGNELSQLTANAVKQFIEENAEKAAMI
Catalytic domain sequence
318 aa
MRVLIVKTSSMGDVLHTLPALTDAQQAIPGIKFDWVVEEGFAQIPSWHAAVERVIPVAIRRWRKAWFSAPIKAERKAFREALQAKNYDAVIDAQGLVKSAALVTRLAHGVKHGMDWQTAREPLASLFYNRKHHIAKQQHAVERTRELFAKSLGYSKPQTQGDYAIAQHFLTNLPTDAGEYAVFLHATTRDDKHWPEEHWRELIGLLADSGIRIKLPWGAPHEEERAKRLAEGFAYVEVLPKMSLEGVARVLAGAKFVVSVDTGLSHLTAALDRPNITVYGPTDPGLIGGYGKNQMVCRAPGNELSQLTANAVKQFIEE
