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waaF
Escherichia coli (strain K12) · Lipopolysaccharide heptosyltransferase 2 (EC 2.4.99.24)
GT9Model organism · annotation ≥ 4Fold GT-BInverting1 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT9 · CAZy entry |
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| Gene symbol | waaF |
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| Synonyms / alternate names | - rfaF
- ADP-heptose:lipopolysaccharide heptosyltransferase II
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| UniProt accession | P37692 |
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| NCBI Gene ID | 75173816; 948135 |
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| Source species | Escherichia coli (strain K12) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Lipopolysaccharide heptosyltransferase 2 (EC 2.4.99.24) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | 1PSW |
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Donor and acceptor specificity
| Sugar nucleotide donor | ADP-L-glycero-beta-D-manno-heptose |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | - an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
- L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
348 aa
MKILVIGPSWVGDMMMSQSLYRTLQARYPQAIIDVMAPAWCRPLLSRMPEVNEAIPMPLGHGALEIGERRKLGHSLREKRYDRAYVLPNSFKSALVPFFAGIPHRTGWRGEMRYGLLNDVRVLDKEAWPLMVERYIALAYDKGIMRTAQDLPQPLLWPQLQVSEGEKSYTCNQFSLSSERPMIGFCPGAEFGPAKRWPHYHYAELAKQLIDEGYQVVLFGSAKDHEAGNEILAALNTEQQAWCRNLAGETQLDQAVILIAACKAIVTNDSGLMHVAAALNRPLVALYGPSSPDFTPPLSHKARVIRLITGYHKVRKGDAAEGYHQSLIDITPQRVLEELNALLLQEEA
Catalytic domain sequence
343 aa
MKILVIGPSWVGDMMMSQSLYRTLQARYPQAIIDVMAPAWCRPLLSRMPEVNEAIPMPLGHGALEIGERRKLGHSLREKRYDRAYVLPNSFKSALVPFFAGIPHRTGWRGEMRYGLLNDVRVLDKEAWPLMVERYIALAYDKGIMRTAQDLPQPLLWPQLQVSEGEKSYTCNQFSLSSERPMIGFCPGAEFGPAKRWPHYHYAELAKQLIDEGYQVVLFGSAKDHEAGNEILAALNTEQQAWCRNLAGETQLDQAVILIAACKAIVTNDSGLMHVAAALNRPLVALYGPSSPDFTPPLSHKARVIRLITGYHKVRKGDAAEGYHQSLIDITPQRVLEELNALL
