Home/GT Families/GT90/POGLUT1
POGLUT1
Homo sapiens · Protein O-glucosyltransferase 1 (EC 2.4.1.376; 2.4.2.63)
GT90Model organism · annotation ≥ 4Fold GT-BInverting6 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT90 · CAZy entry |
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| Gene symbol | POGLUT1 |
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| Synonyms / alternate names | - C3orf9
- CLP46
- KTELC1
- MDSRP
- CAP10-like 46 kDa protein
- KTEL motif-containing protein 1
- Myelodysplastic syndromes relative protein
- O-glucosyltransferase Rumi homolog
- Protein O-xylosyltransferase POGLUT1
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| UniProt accession | Q8NBL1 |
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| NCBI Gene ID | 56983 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Protein O-glucosyltransferase 1 (EC 2.4.1.376; 2.4.2.63) |
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| Subcellular location | Endoplasmic reticulum lumen |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | 5L0R, 5L0S, 5L0T, 5L0U, 5L0V, 5UB5 |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-alpha-D-xylose
- UDP-alpha-D-glucose
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| Donor CCD code(s) | UDX, UPG |
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| Acceptor substrate(s) | L-seryl-[EGF-like domain protein] |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
392 aa
MEWWASSPLRLWLLLFLLPSAQGRQKESGSKWKVFIDQINRSLENYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRKLGTHYQITKNRLYRENDCMFPSRCSGVEHFILEVIGRLPDMEMVINVRDYPQVPKWMEPAIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPIYPTGLGRWDLFREDLVRSAAQWPWKKKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDVAQEIAERGSQFIRNHLQMDDITCYWENLLSEYSKFLSYNVTRRKGYDQIIPKMLKTEL
Catalytic domain sequence
339 aa
SSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRKLGTHYQITKNRLYRENDCMFPSRCSGVEHFILEVIGRLPDMEMVINVRDYPQVPKWMEPAIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPIYPTGLGRWDLFREDLVRSAAQWPWKKKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDVAQEIAERGSQFIRNHLQMDDITCYWENLLSEYSKFLSYNVTRRKGYDQIIPKML
