PLOD3 (GT_NC)

PLOD3

Homo sapiens · Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3

GT_NCModel organism · annotation ≥ 4Fold GT-A18 PDB structure(s)

External resources

UniProt O60568 AlphaFold model InterPro domains NCBI Gene 8985 PDB 6FXK PDB 6FXM PDB 6FXR PDB 6FXT PDB 6FXX PDB 6FXY PDB 6TE3 PDB 6TEC

Identification and annotation

CAZy family	GT_NC
Gene symbol	PLOD3
Synonyms / alternate names	not curated
UniProt accession	`O60568`
NCBI Gene ID	`8985`
Source species	Homo sapiens
Taxonomic domain	Eukaryota
UniProt annotation level	5

Function and localisation

Enzyme function	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Subcellular location	Rough endoplasmic reticulum Endoplasmic reticulum lumen Endoplasmic reticulum membrane Secreted Secreted, extracellular space

Structure and mechanism

Fold type	GT-A
Catalytic mechanism	not curated
Cation dependence	Yes (Mn2+)
Oligomeric state	homodimer
PDB structures	`6FXK`, `6FXM`, `6FXR`, `6FXT`, `6FXX`, `6FXY`, `6TE3`, `6TEC`, `6TES`, `6TEU`, `6TEX`, `6TEZ`, `6WFV`, `8ONE`, `8ZGC`, `8ZGE`, `8ZGG`, `8ZGH`

Donor and acceptor specificity

Sugar nucleotide donor	UDP-alpha-D-galactose UDP-alpha-D-glucose
Donor CCD code(s)	`GDU`, `UPG`
Acceptor substrate(s)	L-lysyl-[collagen] 2-oxoglutarate O2 (5R)-5-hydroxy-L-lysyl-[collagen] (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen]
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

738 aa

MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP

Catalytic domain sequence

not curated