Home/GT Families/GT_NC/let-268
let-268
Caenorhabditis elegans · Multifunctional procollagen lysine hydroxylase and glycosyltransferase
GT_NCModel organism · annotation ≥ 4Fold GT-A
External resources
Identification and annotation
| CAZy family | GT_NC |
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| Gene symbol | let-268 |
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| Synonyms / alternate names | Lethal protein 268 |
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| UniProt accession | Q20679 |
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| NCBI Gene ID | 174564 |
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| Source species | Caenorhabditis elegans |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Multifunctional procollagen lysine hydroxylase and glycosyltransferase |
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| Subcellular location | - Rough endoplasmic reticulum
- Endoplasmic reticulum lumen
- Endoplasmic reticulum membrane
- Secreted
- Secreted, extracellular space
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | not curated |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | homodimer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-alpha-D-galactose
- UDP-alpha-D-glucose
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| Donor CCD code(s) | GDU, UPG |
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| Acceptor substrate(s) | - L-lysyl-[collagen]
- 2-oxoglutarate
- O2
- (5R)-5-hydroxy-L-lysyl-[collagen]
- (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen]
|
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
730 aa
MRVLPFLLPLIPVLLATTITDLPELVVVTVATENTDGLKRLLESAKAFDINIEVLGLGEKWNGGDTRIEQGGGQKIRILSDWIEKYKDASDTMIMFVDAYDVVFNADSTTILRKFFEHYSEKRLLFGAEPFCWPDQSLAPEYPIVEFGKRFLNSGLFMGYGPEMHKILKLKSVEDKDDDQLYYTMIYLDEKLRKELNMDLDSMSKIFQNLNGVIEDVELQFKEDGTPEAYNAAYNTKPLIVHGNGPSKSHLNYLGNYLGNRWNSQLGCRTCGLEVKESEEVPLIALNLFISKPIPFIEEVLQKIAEFDYPKEKIALYIYNNQPFSIKNIQDFLQKHGKSYYTKRVINGVTEIGDREARNEAIEWNKARNVEFAFLMDGDAYFSEPKVIKDLIQYSKTYDVGIIAPMIGQPGKLFTNFWGAIAANGYYARSEDYMAIVKGNRVGYWNVPFITSAVLFNKEKLEAMKDAYSYNKNLDPDMSMCKFARDNGHFLYIDNEKYYGFLIVSDEYAETVTEGKWHPEMWQIFENRELWEARYIHPGYHKIMEPEHVVDQACPDVYDFPLMSERFCEELIEEMEGFGRWSDGSNNDKRLAGGYENVPTRDIHMNQVGFERQWLYFMDTYVRPVQEKTFIGYYHQPVESNMMFVVRYKPEEQPSLRPHHDASTFSIDIALNKKGRDYEGGGVRYIRYNCTVPADEVGYAMMFPGRLTHLHEGLATTKGTRYIMVSFINP
Catalytic domain sequence
not curated
