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Glycoscience Resources, Education, and Training

Glycoscience Resources, Education, and Training

The field of glycoscience, which studies the structure and function of carbohydrates and their derivatives, is essential for advancing biomedical research, bioengineering, and material science. Yet, it remains one of the least understood and most technically challenging areas of molecular biology. To bridge this gap, the National Science Foundation (NSF) has invested in a Biofoundry […]

UGA receives $18M NSF award to democratize glycoscience

UGA receives $18M NSF award to democratize glycoscience

The University of Georgia’s Complex Carbohydrate Research Center (CCRC) has received an $18 million award from the National Science Foundation (NSF) to advance glycoscience accessibility and research. This funding will support the establishment of the BioFoundry: Glycomaterials Research, Education, and Analysis Training (GREAT), an initiative aiming to democratize the study and application of glycoscience. Glycans, […]

NSF invests in BioFoundries to drive advances across science and engineering

NSF invests in BioFoundries to drive advances across science and engineering

The National Science Foundation (NSF) has announced a significant investment in biofoundries designed to advance synthetic biology and biotechnology across multiple research institutions. This initiative will establish facilities capable of integrating cutting-edge technologies like synthetic biology, machine learning, and laboratory automation. The goal is to accelerate innovations and develop sustainable biomanufacturing processes. Among the newly […]

Solid-Phase-Supported Chemoenzymatic Synthesis and Analysis of Chondroitin Sulfate

Solid-Phase-Supported Chemoenzymatic Synthesis and Analysis of Chondroitin Sulfate Proteoglycan Glycopeptides

Chondroitin sulfate proteoglycans (CSPGs) play critical roles in various biological functions, particularly in regulating cellular processes in the nervous system. Their structural complexity arises from glycosaminoglycan (GAG) chains attached to core proteins, which makes understanding their structure-function relationships a scientific challenge. Recent advances have been made using solid-phase-supported chemoenzymatic synthesis to address these complexities and […]

O-GlcNAcylation_ A major nutrient_stress sensor that regulates cellular physiology

O-GlcNAcylation: A major nutrient/stress sensor that regulates cellular physiology

O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine (GlcNAc) to serine or threonine residues on nuclear and cytoplasmic proteins. This process serves as a critical nutrient and stress sensor that influences a wide range of cellular functions, impacting processes such as transcription, protein degradation, and cellular signaling pathways. The dynamic nature of […]