GT-CORE (public beta v1)

Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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UGT1A10

Homo sapiens · UDP-glucuronosyltransferase 1A10 (EC 2.4.1.17)

GT1Model organism · annotation ≥ 4Fold GT-BInverting

External resources

UniProt Q9HAW8AlphaFold modelInterPro domainsNCBI Gene 54575CAZy GT1

Identification and annotation

CAZy familyGT1 · CAZy entry
Gene symbolUGT1A10
Synonyms / alternate names
  • GNT1
  • UGT1
  • UDP-glucuronosyltransferase 1-10
  • UDP-glucuronosyltransferase 1-J
UniProt accessionQ9HAW8
NCBI Gene ID54575
Source speciesHomo sapiens
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme functionUDP-glucuronosyltransferase 1A10 (EC 2.4.1.17)
Subcellular locationEndoplasmic reticulum membrane

Structure and mechanism

Fold typeGT-B
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statehomodimer
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorUDP-alpha-D-glucuronate
Donor CCD code(s)UGA
Acceptor substrate(s)
  • glucuronate acceptor
  • 17beta-estradiol
  • 17alpha-estradiol
  • 16alpha,17beta-estriol
  • 16beta,17beta-estriol
  • 16alpha,17alpha-estriol
  • 16alpha-hydroxyestrone
  • estrone
  • prunetin
  • (5Z,8Z,11Z,14Z)-eicosatetraenoate
  • 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
  • prostaglandin B1
  • (E)-ferulate
  • losartan
  • candesartan
  • zolasartan
Acceptor CCD / GlycoCTEST Verified PDB CCD code

Protein sequences

Full protein sequence

530 aa 
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Catalytic domain sequence

416 aa 
LLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSL
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