Home/GT Families/GT1/UGT1A1
UGT1A1
Homo sapiens · UDP-glucuronosyltransferase 1A1 (EC 2.4.1.17)
GT1Model organism · annotation ≥ 4Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
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| Gene symbol | UGT1A1 |
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| Synonyms / alternate names | - GNT1
- UGT1
- Bilirubin-specific UDPGT isozyme 1
- UDP-glucuronosyltransferase 1-1
- UDP-glucuronosyltransferase 1A isoform 1
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| UniProt accession | P22309 |
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| NCBI Gene ID | 54658 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | UDP-glucuronosyltransferase 1A1 (EC 2.4.1.17) |
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| Subcellular location | - Endoplasmic reticulum membrane
- Cytoplasm, perinuclear region
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucuronate |
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| Donor CCD code(s) | UGA |
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| Acceptor substrate(s) | - glucuronate acceptor
- 17beta-estradiol
- 2-hydroxyestrone
- 2-hydroxy-17beta-estradiol
- 2-methoxy-17beta-estradiol
- 17alpha-estradiol
- 16beta,17beta-estriol
- losartan
- prunetin
- SN-38
- (4Z,15Z)-bilirubin IXalpha
- (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside
- (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside
- 8-iso-prostaglandin F2alpha
- (5Z,8Z,11Z,14Z)-eicosatetraenoate
- 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
- 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate
- prostaglandin B1
- (E)-ferulate
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| Acceptor CCD / GlycoCT | EST Verified PDB CCD code |
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Protein sequences
Full protein sequence
533 aa
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Catalytic domain sequence
418 aa
KILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSL
