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Pofut4
Rattus norvegicus · GDP-fucose protein O-fucosyltransferase 4 (EC 2.4.1.221; 2.4.1.-)
GT10Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT10 · CAZy entry |
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| Gene symbol | Pofut4 |
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| Synonyms / alternate names | - Fut11
- Alpha-(1,3)-fucosyltransferase 11
- Fucosyltransferase XI
- Galactoside 3-L-fucosyltransferase 11
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| UniProt accession | Q68FV3 |
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| NCBI Gene ID | 286971 |
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| Source species | Rattus norvegicus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | GDP-fucose protein O-fucosyltransferase 4 (EC 2.4.1.221; 2.4.1.-) |
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| Subcellular location | Endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | - L-threonyl-[protein]
- L-seryl-[protein]
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
494 aa
MAARYTEAVLAALGVLSVCSASSSSGSGASGKAGGEAEWAEPWDGAVFRPPAALGAVGMTRGLGSPPPGNAETVDLPVLLWWSPGLFPHFPGDSERIECALGACVASRDRRARADPRTRALLFYGTDFRAADAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTATFSRHSDYPLPLQWLPGAAYLRRPAPPLRERAEWRRRGYAPLLYLQSHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPTVRLQDTATATTEDPELMAFLSRYKFHLAMENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKQPGGITNQFLLDNLEHREWGVNDPMLPNYLNGFECFVCDHELARLDAEKAHESSPRDIPVLEPHIAQLSHMDCPVPTPGFGKVEEIPENDSWKEMWLQDYWQGLYQGEALTAMIHNNETQQSKFWDYVHEIFMKRNKNL
Catalytic domain sequence
144 aa
YLQSHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPTVRLQDTATATTEDPELMAFLSRYKFHLAMENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKQP
