Home/GT Families/GT12/B4GALNT1
B4GALNT1
Homo sapiens · Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92)
GT12Model organism · annotation ≥ 4Fold GT-AInverting3 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT12 · CAZy entry |
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| Gene symbol | B4GALNT1 |
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| Synonyms / alternate names | - GALGT
- SIAT2
- (N-acetylneuraminyl)-galactosylglucosylceramide
- GM2/GD2 synthase
- GalNAc-T
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| UniProt accession | Q00973 |
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| NCBI Gene ID | 2583 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | 9H6J, 9H6K, 9H6L |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-galactosamine |
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| Donor CCD code(s) | UD2 |
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| Acceptor substrate(s) | - a ganglioside GM3 (d18:1(4E))
- a ganglioside GM3
- a ganglioside GD3
- a ganglioside GD3 (d18:1(4E))
- a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
- a ganglioside GD1a
- a ganglioside GT3 (d18:1(4E))
- a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
- a neolactoside IV(3)-alpha-NeuGc-nLc4Cer
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
533 aa
MWLGRRALCALVLLLACASLGLLYASTRDAPGLRLPLAPWAPPQSPRRPELPDLAPEPRYAHIPVRIKEQVVGLLAWNNCSCESSGGGLPLPFQKQVRAIDLTKAFDPAELRAASATREQEFQAFLSRSQSPADQLLIAPANSPLQYPLQGVEVQPLRSILVPGLSLQAASGQEVYQVNLTASLGTWDVAGEVTGVTLTGEGQADLTLVSPGLDQLNRQLQLVTYSSRSYQTNTADTVRFSTEGHEAAFTIRIRHPPNPRLYPPGSLPQGAQYNISALVTIATKTFLRYDRLRALITSIRRFYPTVTVVIADDSDKPERVSGPYVEHYLMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLERLVDVLERTPLDLVGGAVREISGFATTYRQLLSVEPGAPGLGNCLRQRRGFHHELVGFPGCVVTDGVVNFFLARTDKVREVGFDPRLSRVAHLEFFLDGLGSLRVGSCSDVVVDHASKLKLPWTSRDAGAETYARYRYPGSLDESQMAKHRLLFFKHRLQCMTSQ
Catalytic domain sequence
164 aa
IATKTFLRYDRLRALITSIRRFYPTVTVVIADDSDKPERVSGPYVEHYLMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLERLVDVLERTPLDLVGGAVREISGFATTYRQLLSVEPGAPGLGNCLRQRRGFHHELVGFPGCVVTDGVVNFFLARTD
