Home/GT Families/GT12/B4GALNT2
B4GALNT2
Homo sapiens · N-acetylneuraminylgalactosylglucosyl-glucoside beta-1,4-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.165)
GT12Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT12 · CAZy entry |
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| Gene symbol | B4GALNT2 |
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| Synonyms / alternate names | - GALGT2
- Beta-1,4 N-acetylgalactosaminyltransferase 2
- Sd(a) beta-1,4-GalNAc transferase
- UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase
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| UniProt accession | Q8NHY0 |
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| NCBI Gene ID | 124872 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | N-acetylneuraminylgalactosylglucosyl-glucoside beta-1,4-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.165) |
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| Subcellular location | - Golgi apparatus, trans-Golgi network membrane
- Cytoplasmic vesicle membrane
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-galactosamine |
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| Donor CCD code(s) | UD2 |
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| Acceptor substrate(s) | - an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative
- a 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-seryl-[protein]
- a 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein]
- a neolactoside IV(3)-alpha-NeuAc-nLc4Cer
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
566 aa
MGSAGFSVGKFHVEVASRGRECVSGTPECGNRLGSAGFGALCLELRGADPAWGPFAAHGRSRRQGSRFLWLLKILVIILVLGIVGFMFGSMFLQAVFSSPKPELPSPAPGVQKLKLLPEERLRNLFSYDGIWLFPKNQCKCEANKEQGGYNFQDAYGQSDLPAVKARRQAEFEHFQRREGLPRPLPLLVQPNLPFGYPVHGVEVMPLHTVPIPGLQFEGPDAPVYEVTLTASLGTLNTLADVPDSVVQGRGQKQLIISTSDRKLLKFILQHVTYTSTGYQHQKVDIVSLESRSSVAKFPVTIRHPVIPKLYDPGPERKLRNLVTIATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEETKIEVLVDVLEKTELDVVGGSVLGNVFQFKLLLEQSENGACLHKRMGFFQPLDGFPSCVVTSGVVNFFLAHTERLQRVGFDPRLQRVAHSEFFIDGLGTLLVGSCPEVIIGHQSRSPVVDSELAALEKTYNTYRSNTLTRVQFKLALHYFKNHLQCAA
Catalytic domain sequence
107 aa
ATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEETKIEVLVDVLEKTELDVVGGSVLG
