CHS1 (GT2)

CHS1

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) · Chitin synthase 1 (EC 2.4.1.16)

GT2Model organism · annotation ≥ 4Fold GT-AInverting10 PDB structure(s)

External resources

UniProt P08004 AlphaFold model InterPro domains NCBI Gene 855529 CAZy GT2 PDB 7XS6 PDB 7XS7 PDB 8K3P PDB 8K3Q PDB 8K3R PDB 8K3T PDB 8K3U PDB 8K3V

Identification and annotation

CAZy family	GT2 · CAZy entry
Gene symbol	CHS1
Synonyms / alternate names	Chitin-UDP acetyl-glucosaminyl transferase 1
UniProt accession	`P08004`
NCBI Gene ID	`855529`
Source species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomic domain	Eukaryota
UniProt annotation level	5

Function and localisation

Enzyme function	Chitin synthase 1 (EC 2.4.1.16)
Subcellular location	Cell membrane

Structure and mechanism

Fold type	GT-A
Catalytic mechanism	Inverting
Cation dependence	No
Oligomeric state	not curated
PDB structures	`7XS6`, `7XS7`, `8K3P`, `8K3Q`, `8K3R`, `8K3T`, `8K3U`, `8K3V`, `8K3W`, `8K3X`

Donor and acceptor specificity

Sugar nucleotide donor	UDP-N-acetyl-alpha-D-glucosamine
Donor CCD code(s)	`UD1`
Acceptor substrate(s)	[(1->4)-N-acetyl-beta-D-glucosaminyl](n)
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

1131 aa

MSDQNNRSRNEYHSNRKNEPSYELQNAHSGLFHSSNEELTNRNQRYTNQNASMGSFTPVQSLQFPEQSQQTNMLYNGDDGNNNTINDNERDIYGGFVNHHRQRPPPATAEYNDVFNTNSQQLPSEHQYNNVPSYPLPSINVIQTTPELIHNGSQTMATPIERPFFNENDYYYNNRNSRTSPSIASSSDGYADQEARPILEQPNNNMNSGNIPQYHDQPFGYNNGYHGLQAKDYYDDPEGGYIDQRGDDYQINSYLGRNGEMVDPYDYENSLRHMTPMERREYLHDDSRPVNDGKEELDSVKSGYSHRDLGEYDKDDFSRDDEYDDLNTIDKLQFQANGVPASSSVSSIGSKESDIIVSNDNLTANRALKRSGTEIRKFKLWNGNFVFDSPISKTLLDQYATTTENANTLPNEFKFMRYQAVTCEPNQLAEKNFTVRQLKYLTPRETELMLVVTMYNEDHILLGRTLKGIMDNVKYMVKKKNSSTWGPDAWKKIVVCIISDGRSKINERSLALLSSLGCYQDGFAKDEINEKKVAMHVYEHTTMINITNISESEVSLECNQGTVPIQLLFCLKEQNQKKINSHRWAFEGFAELLRPNIVTLLDAGTMPGKDSIYQLWREFRNPNVGGACGEIRTDLGKRFVKLLNPLVASQNFEYKMSNILDKTTESNFGFITVLPGAFSAYRFEAVRGQPLQKYFYGEIMENEGFHFFSSNMYLAEDRILCFEVVTKKNCNWILKYCRSSYASTDVPERVPEFILQRRRWLNGSFFASVYSFCHFYRVWSSGHNIGRKLLLTVEFFYLFFNTLISWFSLSSFFLVFRILTVSIALAYHSAFNVLSVIFLWLYGICTLSTFILSLGNKPKSTEKFYVLTCVIFAVMMIYMIFCSIFMSVKSFQNILKNDTISFEGLITTEAFRDIVISLGSTYCLYLISSIIYLQPWHMLTSFIQYILLSPSYINVLNIYAFCNVHDLSWGTKGAMANPLGKINTTEDGTFKMEVLVSSSEIQANYDKYLKVLNDFDPKSESRPTEPSYDEKKTGYYANVRSLVIIFWVITNFIIVAVVLETGGIADYIAMKSISTDDTLETAKKAEIPLMTSKASIYFNVILWLVALSALIRFIGCSIYMIVRFFKKVTFR

Catalytic domain sequence

316 aa

VTMYNEDHILLGRTLKGIMDNVKYMVKKKNSSTWGPDAWKKIVVCIISDGRSKINERSLALLSSLGCYQDGFAKDEINEKKVAMHVYEHTTMINITNISESEVSLECNQGTVPIQLLFCLKEQNQKKINSHRWAFEGFAELLRPNIVTLLDAGTMPGKDSIYQLWREFRNPNVGGACGEIRTDLGKRFVKLLNPLVASQNFEYKMSNILDKTTESNFGFITVLPGAFSAYRFEAVRGQPLQKYFYGEIMENEGFHFFSSNMYLAEDRILCFEVVTKKNCNWILKYCRSSYASTDVPERVPEFILQRRRWLNGSFFA