Home/GT Families/GT2/CLUP02_10320
CLUP02_10320
Colletotrichum lupini · Ketol-acid reductoisomerase, mitochondrial (EC 1.1.1.86; 2.3.2.23; 2.3.2.34; 2.4.1.16)
GT2Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | CLUP02_10320 |
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| Synonyms / alternate names | - Acetohydroxy-acid reductoisomerase
- Alpha-keto-beta-hydroxylacyl reductoisomerase
- NEDD8-conjugating enzyme Ubc12
- RUB1-conjugating enzyme
- Ubiquitin carrier protein 12
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| UniProt accession | A0A9Q8SWE3 |
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| NCBI Gene ID | 73344306 |
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| Source species | Colletotrichum lupini |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Ketol-acid reductoisomerase, mitochondrial (EC 1.1.1.86; 2.3.2.23; 2.3.2.34; 2.4.1.16) |
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| Subcellular location | - Cell membrane
- Mitochondrion
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mg2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | - [(1->4)-N-acetyl-beta-D-glucosaminyl](n)
- [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
- [E2 NEDD8-conjugating enzyme]-L-cysteine
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
2223 aa
MGPLDIHGASAGAFAQVVLFSYSSCKNAMPGLSSAKPQLPQSVDIRLWGSPGKKERTTVPVRYNTTYVAKAGKQAGEGCRSDFSFSHAAPSPCTLKLSARCRVPILIFAHLSPVGPILELFSSILTTSAILSTWRFHARSHLAAGFWFPPSKAASPSGPFFNHLLPHPASPPSPLLLLLPPSPPSIFTSFSFFSSFASPIVTGVVAFLAAHLSNLQRLSIMAYRGGHENDYDGGHNMQDLPPGSGRGYHLPPQDEGVDEAGQSLLRDPHAPAPYESHLGTGETPGRPVSAYSLTESYAPGAGARTPVPGETAFASGYSNELDSDAGGFGYGNRPPSTVDADESWTRRQQPGNQGGGLKRYATRKIKLTQGSVLSIDYPVPSAIKNAVQPKYRDVEGGSEEFMKMRYTAATCDPNDFTLKNGYDLRPRMYNRHTELLIAITYYNEDKVLLSRTLHGVMQNIRDIVNLKKSTFWNKGGPAWQKIVVCLVFDGIEKTDKAVLDVLATVGIYQDGVVKKDVDGKETVAHIFEYTSQLSVTPNQQLIRPVDDGPSTLPPVQFIFCLKQKNSKKINSHRWLFNAFGRILNPEVCILIDAGTKPSPRSLLALWEGFYNDKDLGGACGEIHAMLGKGGKKLLNPLVAVQNFEYKISNILDKPLESSFGYVSVLPGAFSAYRFRAIMGRPLEQYFHGDHTLSKILGKKGIDGMNIFKKNMFLAEDRILCFELVAKAGQKWHLSYIKAAKGETDVPEGAAEFISQRRRWLNGSFAASLYSLMHFGRMYKSGHNIIRMFFFHVQLIYNILQVMFTWFSLGSYYLTTTVIMDLVGTAVTSDDPDVARSGWPFGDTATPIVNALLKYLYLAFVILQFILALGNRPKGSKYTYIASFVVFGLIQSYILVLSMYLVVQAFQKPIGEQISLDSGEDFVASFFGGTNAAGVILVALVTIYGLNFIASFMYLDPWHMFTSFPHYLVLMSTYINILMVYAFNNWHDVSWGTKGSDSTEALPSAHVSKGEKDEAVVEEIDKPQEDIDSQFESTVKRALEPFKETPENEKPDIEDSYKSFRTGLVVSWLFSNTFLIIVITSDNFNSFGIGKTASARTASYFSFLLYSTAVLSLTVNRQTEEIVQTGAEPLDACWMCIRGKTVLLPALAHCYESAGVFHSGHVLSNKGHGTRQILDEVGGSSKLPANLAALQRACVLSWLSLHFFIYSDCCCSMLFNDRGLRQADKSGSSRSAPPGTFPSQDRKTPDRDDYLILNLLFNCLVTAQTPLIQENTIFHPGRVRALVPRLTLLTERPTNSSHQTPRQRSDKMLKIWSMKKEQQKAENADAAGGKKKKVTAAQLRVQKDLSELSLGSTMKTDFPDADDILHFTLTIEPDEGMYRTGRFTFTFDINQNFPHEPPKVRCKEKIYHPNIDLEGKVCLNILREDWKPVLNLNAVIVGLQFLFLEPNASDPLNKEAADDLRLNREGFKRNVRTAMGGGTVQGQSYDRTRGQPEFDTRDGRTGCWFAEGWNAHLKGRWASKASIVVRRLGRQDYKLQQVKVLARHQAQFRDSTSEGAAQKGSLMRRGRRKSIAGMQTALPCHGRRRSKHGELKPITGPIDSPIMQLSAGDRSTAVAAERGRRHRSTAVAGAHVVGSPLLHSTRLAGNNYPLSHLEDPLPNPGRFQTSSPPLAQASSRTTQQANPPTTKLGRSRGETLFSSSISSFFFLTIDLYGYPLHSLLPQHTVRMASRSFSKALRSPMARQLAAKPATQQRTFVAARQLVRASAQVNKAFVAPAQQQARGVKTMDFAGHKEDVYERADWPQEKLLEYFKDDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKNGQSWKDAQQDGWVPGKNLFDVDEAISRGTIVMNLLSDAAQSETWPAIKPQLVKGKTLYFSHGFSPVFKDVTHVDVPKDIDVILVAPKGSGRTVRSLFREGRGINSSFAVFQDVTGKAKEKAQALGVAIGSGYLYETTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGANGMDWMYEACSTTARRGAIDWSPKFKDALKPVFNSLYDAVKDGSETKRSLEYNSQKDYRQKFEAEMEEIRNLEIWRAGRAVRSLRPENQNLHLDFWDPSIPFLLLSMNTICRVMQGPKTDSSGPLILYTDCANCCWTETKLAPPRPRGGVVLHAAASFMAMLSPRSGLQKYSLRCSVKFEHAR
Catalytic domain sequence
340 aa
LLIAITYYNEDKVLLSRTLHGVMQNIRDIVNLKKSTFWNKGGPAWQKIVVCLVFDGIEKTDKAVLDVLATVGIYQDGVVKKDVDGKETVAHIFEYTSQLSVTPNQQLIRPVDDGPSTLPPVQFIFCLKQKNSKKINSHRWLFNAFGRILNPEVCILIDAGTKPSPRSLLALWEGFYNDKDLGGACGEIHAMLGKGGKKLLNPLVAVQNFEYKISNILDKPLESSFGYVSVLPGAFSAYRFRAIMGRPLEQYFHGDHTLSKILGKKGIDGMNIFKKNMFLAEDRILCFELVAKAGQKWHLSYIKAAKGETDVPEGAAEFISQRRRWLNGSFAASLYSLMHF
