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DPM1
Sus scrofa · Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83)
GT2Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | DPM1 |
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| Synonyms / alternate names | - Dolichol-phosphate mannose synthase subunit 1
- Dolichyl-phosphate beta-D-mannosyltransferase subunit 1
- Mannose-P-dolichol synthase subunit 1
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| UniProt accession | A5GFZ5 |
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| NCBI Gene ID | 100124379 |
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| Source species | Sus scrofa |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) |
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| Subcellular location | Endoplasmic reticulum |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mg2+, Mn2+, Ca2+) |
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| Oligomeric state | Component of the dolichol-phosphate mannose (DPM) synthase c |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-alpha-D-mannose |
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| Donor CCD code(s) | GDD |
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| Acceptor substrate(s) | - a di-trans
- poly-cis-dolichyl phosphate
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
259 aa
MASEEASRNSRSRWEPEGRFPRQDKYSVLLPTYNERENLPLIVWLLVKSFSESGINYEIIIIDDGSPDGTRDIAEQLVKIYGSDKILLRPREKKLGLGTAYIHGMKHATGNYIIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFITQILLRPGASDLTGSFRLYRKEVLQKLIEKCVSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT
Catalytic domain sequence
171 aa
SVLLPTYNERENLPLIVWLLVKSFSESGINYEIIIIDDGSPDGTRDIAEQLVKIYGSDKILLRPREKKLGLGTAYIHGMKHATGNYIIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFITQILLRPGASDLTGSFRLYRKEVLQKL
