Home/GT Families/GT2/DPM1
DPM1
Homo sapiens · Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83)
GT2Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
|---|
| Gene symbol | DPM1 |
|---|
| Synonyms / alternate names | - Dolichol-phosphate mannose synthase subunit 1
- Dolichyl-phosphate beta-D-mannosyltransferase subunit 1
- Mannose-P-dolichol synthase subunit 1
|
|---|
| UniProt accession | O60762 |
|---|
| NCBI Gene ID | 8813 |
|---|
| Source species | Homo sapiens |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) |
|---|
| Subcellular location | Endoplasmic reticulum |
|---|
Structure and mechanism
| Fold type | GT-A |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | Yes (Mg2+, Mn2+, Ca2+) |
|---|
| Oligomeric state | Component of the dolichol-phosphate mannose (DPM) synthase c |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | GDP-alpha-D-mannose |
|---|
| Donor CCD code(s) | GDD |
|---|
| Acceptor substrate(s) | - a di-trans
- poly-cis-dolichyl phosphate
|
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
260 aa
MASLEVSRSPRRSRRELEVRSPRQNKYSVLLPTYNERENLPLIVWLLVKSFSESGINYEIIIIDDGSPDGTRDVAEQLEKIYGSDRILLRPREKKLGLGTAYIHGMKHATGNYIIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFLTQILLRPGASDLTGSFRLYRKEVLEKLIEKCVSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT
Catalytic domain sequence
228 aa
VLLPTYNERENLPLIVWLLVKSFSESGINYEIIIIDDGSPDGTRDVAEQLEKIYGSDRILLRPREKKLGLGTAYIHGMKHATGNYIIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFLTQILLRPGASDLTGSFRLYRKEVLEKLIEKCVSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTL
