Home/GT Families/GT2/DPM1
DPM1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) · Dolichol-phosphate mannosyltransferase (EC 2.4.1.83)
GT2Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | DPM1 |
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| Synonyms / alternate names | - SED3
- Dolichol-phosphate mannose synthase
- Dolichyl-phosphate beta-D-mannosyltransferase
- Mannose-P-dolichol synthase
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| UniProt accession | P14020 |
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| NCBI Gene ID | 856313 |
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| Source species | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) |
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| Subcellular location | Endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mg2+, Mn2+, Ca2+) |
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| Oligomeric state | Interacts with the C-terminus of SAC1, thereby sequestering |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-alpha-D-mannose |
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| Donor CCD code(s) | GDD |
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| Acceptor substrate(s) | - a di-trans
- poly-cis-dolichyl phosphate
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
267 aa
MSIEYSVIVPAYHEKLNIKPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEAKGQYLVCMDADLQHPPETVPKLFESLHDHAFTLGTRYAPGVGIDKDWPMYRRVISSTARMMARPLTIASDPMSGFFGLQKKYLENCNPRDINSQGFKIALELLAKLPLPRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKELYVFKFGANNLILFITFWSILFFYVCYQLYHLVF
Catalytic domain sequence
228 aa
VIVPAYHEKLNIKPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEAKGQYLVCMDADLQHPPETVPKLFESLHDHAFTLGTRYAPGVGIDKDWPMYRRVISSTARMMARPLTIASDPMSGFFGLQKKYLENCNPRDINSQGFKIALELLAKLPLPRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKEL
