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has2
Xenopus tropicalis · Hyaluronan synthase 2 (EC 2.4.1.212)
GT2Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | has2 |
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| Synonyms / alternate names | - Hyaluronate synthase 2
- Hyaluronic acid synthase 2
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| UniProt accession | B1WAU6 |
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| NCBI Gene ID | 100145711 |
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| Source species | Xenopus tropicalis |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Hyaluronan synthase 2 (EC 2.4.1.212) |
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| Subcellular location | - Cell membrane
- Endoplasmic reticulum membrane
- Golgi apparatus membrane
- Lysosome
- Vesicle
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mg2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-alpha-D-glucuronate
- UDP-N-acetyl-alpha-D-glucosamine
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| Donor CCD code(s) | UGA, UD1 |
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| Acceptor substrate(s) | - N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n)
- [hyaluronan](n)
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
552 aa
MHCERFICILRIIGTTLFGVSLLLGISAAYIVGYQFIQTDNYYFSFGLYGAILALHLIIQSLFAFLEHRKMKRSLETPIKLNKSVALCIAAYQEDPDYLRKCLLSVKRLTYPGMKVIMVIDGNSDDDLYMMDIFREIMGSDSCATYVWKNNFHLKGPNETDGSHRESMQHVTQMVLSNKNVCIMQKWGGKREVMYTAFKALGRSVDYVQVCDSDTVLDPASSVEMVKVLEEDIMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFLEDWYNQEFLGSQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPTEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAVITGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGLIKSSFASALRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPITVWFTILLGGVCYTIWRETKKPFSESEKIVLAVGAILYACYWVMLLTMYVSLVMKCGRRRKEPQHDLVLDV
Catalytic domain sequence
278 aa
SVALCIAAYQEDPDYLRKCLLSVKRLTYPGMKVIMVIDGNSDDDLYMMDIFREIMGSDSCATYVWKNNFHLKGPNETDGSHRESMQHVTQMVLSNKNVCIMQKWGGKREVMYTAFKALGRSVDYVQVCDSDTVLDPASSVEMVKVLEEDIMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFLEDWYNQEFLGSQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPTEYLRWLNQQTRWSKSYFRE
