Home/GT Families/GT2/has3
has3
Xenopus laevis · Hyaluronan synthase 3 (EC 2.4.1.212)
GT2Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
|---|
| Gene symbol | has3 |
|---|
| Synonyms / alternate names | - Hyaluronate synthase 3
- Hyaluronic acid synthase 3
|
|---|
| UniProt accession | O57426 |
|---|
| NCBI Gene ID | not curated |
|---|
| Source species | Xenopus laevis |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 4 |
|---|
Function and localisation
| Enzyme function | Hyaluronan synthase 3 (EC 2.4.1.212) |
|---|
| Subcellular location | - Cell membrane
- Golgi apparatus membrane
- Golgi apparatus, trans-Golgi network membrane
- Cytoplasmic vesicle
|
|---|
Structure and mechanism
| Fold type | GT-A |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | Yes (Mg2+) |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-N-acetyl-alpha-D-glucosamine
- UDP-alpha-D-glucuronate
|
|---|
| Donor CCD code(s) | UD1, UGA |
|---|
| Acceptor substrate(s) | - [hyaluronan](n)
- N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n)
|
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
557 aa
MPGKFQTGLRVLATCLFALLVLGGILVAYVTGYQFIHTDRHHLSFGLYGAILGLHLLSQSLFAFLEHRKMRGGGRCPSGKSTVVLCIAAYQEDPEYLRKCLRSVRRLSYPHLRVIMVVDGNTEEDRYMMDIFREVMGSEGTCCYIWDKNYHESEEGGQEGERGVQEMVKNFQYVCIMQKWGGKREVTYTAFRALGDSVAYVQVCDSDTVLDPACTAEMLRILEEDPEVGGVGGDVQILNKYESWISFLSSFRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQYFLEDWYHQTFLGQKCSFGDDRHLTNRVLSMGFRTKYTARSRCLTETPTRYLRWLNQQTRWSKSYFREWLYNALWFHKHHLWMTYESVVTGFFPFFLVATVVQLFYRGRVWNILLFLLTVQLVGILKATYACILRGNAEMIFMSLYSLLYMTSLLPAKIFAVITIKKSGWGTSGRRKLVVNFMGMVPVSVWFCILLGGLVYTAYCQSHDPFTETELLFLLTGAILYGCYWVALLSLYLALIARRCGKRQELYNLALEEVSEPEPAAKAIKP
Catalytic domain sequence
273 aa
TVVLCIAAYQEDPEYLRKCLRSVRRLSYPHLRVIMVVDGNTEEDRYMMDIFREVMGSEGTCCYIWDKNYHESEEGGQEGERGVQEMVKNFQYVCIMQKWGGKREVTYTAFRALGDSVAYVQVCDSDTVLDPACTAEMLRILEEDPEVGGVGGDVQILNKYESWISFLSSFRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQYFLEDWYHQTFLGQKCSFGDDRHLTNRVLSMGFRTKYTARSRCLTETPTRYLRWLNQQTRWSKSYFRE
