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kfoC
Escherichia coli · Chondroitin synthase
GT2Model organism · annotation ≥ 4Fold GT-AInverting2 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | kfoC |
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| Synonyms / alternate names | Chondroitin polymerase |
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| UniProt accession | Q8L0V4 |
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| NCBI Gene ID | not curated |
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| Source species | Escherichia coli |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Chondroitin synthase |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | 2Z86, 2Z87 |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-N-acetyl-alpha-D-galactosamine
- UDP-alpha-D-glucuronate
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| Donor CCD code(s) | UD2, UGA |
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| Acceptor substrate(s) | - 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
- 3-O-{beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]
- 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
- 3-O-{[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
686 aa
MSILNQAINLYKNKNYRQALSLFEKVAEIYDVSWVEANIKLCQTALNLSEEVDKLNRKAVIDIDAATKIMCSNAKAISLNEVEKNEIISKYREITAKKSERAELKEVEPIPLDWPSDLTLPPLPESTNDYVWAGKRKELDDYPRKQLIIDGLSIVIPTYNRAKILAITLACLCNQKTIYDYEVIVADDGSKENIEEIVREFESLLNIKYVRQKDYGYQLCAVRNLGLRAAKYNYVAILDCDMAPNPLWVQSYMELLAVDDNVALIGPRKYIDTSKHTYLDFLSQKSLINEIPEIITNNQVAGKVEQNKSVDWRIEHFKNTDNLRLCNTPFRFFSGGNVAFAKKWLFRAGWFDEEFTHWGGEDNEFGYRLYREGCYFRSVEGAMAYHQEPPGKENETDRAAGKNITVQLLQQKVPYFYRKKEKIESATLKRVPLVSIYIPAYNCSKYIVRCVESALNQTITDLEVCICDDGSTDDTLRILQEHYANHPRVRFISQKNKGIGSASNTAVRLCRGFYIGQLDSDDFLEPDAVELCLDEFRKDLSLACVYTTNRNIDREGNLISNGYNWPIYSREKLTSAMICHHFRMFTARAWNLTEGFNESISNAVDYDMYLKLSEVGPFKHINKICYNRVLHGENTSIKKLDIQKENHFKVVNESLSRLGIKKYKYSPLTNLNECRKYTWEKIENDL
Catalytic domain sequence
433 aa
SIVIPTYNRAKILAITLACLCNQKTIYDYEVIVADDGSKENIEEIVREFESLLNIKYVRQKDYGYQLCAVRNLGLRAAKYNYVAILDCDMAPNPLWVQSYMELLAVDDNVALIGPRKYIDTSKHTYLDFLSQKSLINEIPEIITNNQVAGKVEQNKSVDWRIEHFKNTDNLRLCNTPFRFFSGGNVAFAKKWLFRAGWFDEEFTHWGGEDNEFGYRLYREGCYFRSVEGAMAYHQEPPGKENETDRAAGKNITVQLLQQKVPYFYRKKEKIESATLKRVPLVSIYIPAYNCSKYIVRCVESALNQTITDLEVCICDDGSTDDTLRILQEHYANHPRVRFISQKNKGIGSASNTAVRLCRGFYIGQLDSDDFLEPDAVELCLDEFRKDLSLACVYTTNRNIDREGNLISNGYNWPIYSREKLTSAMICHHFRMF
