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TPS1
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) · Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit (EC 2.4.1.15)
GT20Non-model organism · annotation 4–5Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT20 · CAZy entry |
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| Gene symbol | TPS1 |
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| Synonyms / alternate names | - GGS1
- Trehalose-6-phosphate synthase
- UDP-glucose-glucosephosphate glucosyltransferase
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| UniProt accession | Q07158 |
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| NCBI Gene ID | 2896906 |
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| Source species | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit (EC 2.4.1.15) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | No |
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| Oligomeric state | Trehalose synthase/phosphatase complex contains three or fou |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucose |
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| Donor CCD code(s) | UPG |
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| Acceptor substrate(s) | D-glucose 6-phosphate |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
488 aa
MVNQDISKLSLNECPGSVIVISNRLPVTIKKDEKTGEYEYSMSSGGLVTALQGLKKSTTFQWYGWPGLEVPDEDKAKVKRELLEKFNAIPIFLSDEVADLHYNGFSNSILWPLFHYHPGEITFDDTAWLAYNEANMAFADEIEGNINDNDVVWVHDYHLMLLPEMIRQRVIAKKLKNIKIGWFLHTPFPSSEIYRILPVRQEILKGVLSCDLIGFHTYDYARHFLSAVQRILNVNTLPNGVEFDGRFVNVGAFPIGIDVETFTEGLKQDAVIKRIKELKESFKGCKIIIGVDRLDYIKGVPQKLHALEVFLGAHPEWIGKVVLVQVAVPSRGDVEEYQYLRSVVNELVGRINGQFGTAEFVPIHFMHRSIPFQELISLYAVSDVCLVSSTRDGMNLVSYEYISCQEEKKGTLILSEFTGAAQSLNGALIVNPWNTDDLAESINEALTVPEEKRAANWEKLYKYISKYTSAFWGENFVHELYRLGSSNN
Catalytic domain sequence
465 aa
SVIVISNRLPVTIKKDEKTGEYEYSMSSGGLVTALQGLKKSTTFQWYGWPGLEVPDEDKAKVKRELLEKFNAIPIFLSDEVADLHYNGFSNSILWPLFHYHPGEITFDDTAWLAYNEANMAFADEIEGNINDNDVVWVHDYHLMLLPEMIRQRVIAKKLKNIKIGWFLHTPFPSSEIYRILPVRQEILKGVLSCDLIGFHTYDYARHFLSAVQRILNVNTLPNGVEFDGRFVNVGAFPIGIDVETFTEGLKQDAVIKRIKELKESFKGCKIIIGVDRLDYIKGVPQKLHALEVFLGAHPEWIGKVVLVQVAVPSRGDVEEYQYLRSVVNELVGRINGQFGTAEFVPIHFMHRSIPFQELISLYAVSDVCLVSSTRDGMNLVSYEYISCQEEKKGTLILSEFTGAAQSLNGALIVNPWNTDDLAESINEALTVPEEKRAANWEKLYKYISKYTSAFWGENFVHELY
