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otsA
Mycobacterium marinum (strain ATCC BAA-535 / M) · Trehalose-6-phosphate synthase (EC 2.4.1.15; 2.4.1.347)
GT20Non-model organism · annotation 4–5Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT20 · CAZy entry |
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| Gene symbol | otsA |
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| Synonyms / alternate names | - Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
- Osmoregulatory trehalose synthesis protein A
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| UniProt accession | B2HHY2 |
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| NCBI Gene ID | 34340145 |
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| Source species | Mycobacterium marinum (strain ATCC BAA-535 / M) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Trehalose-6-phosphate synthase (EC 2.4.1.15; 2.4.1.347) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | No |
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| Oligomeric state | homotetramer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | - ADP-alpha-D-glucose
- CDP-alpha-D-glucose
- GDP-alpha-D-glucose
- TDP-alpha-D-glucose
- UDP-alpha-D-glucose
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| Donor CCD code(s) | ADQ, GDG, UPG |
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| Acceptor substrate(s) | D-glucose 6-phosphate |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
500 aa
MGPGGRQSAEPASTEVFGDSDFVVVANRLPVDQERLPDGTIAWKRSPGGLVTALEPLLRRRRGAWVGWAGVVENDVDVQDEPIVQDELQLQPVRLSADDVAQYYEGFSNATLWPLYHDVIVRPIYHREWWDRYVDVNRRFAEATARAAARGGTVWVQDYQLQLVPKMLRAMRPDLTIGFFLHIPFPPVELFMQLPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGADTSRGTVGVRSRFGEVILGSRTIRVGAFPISIDSGALDQTARDRNIRRRSREIRAELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVESYQTLRNDIERQVGHINGEYAEVGHPVVHYLHRPVPRNELIAFFVASDVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALNQTEEAGRRRMRSMRRQVLAHDVDRWARSFLDALADSRPNDSADAAD
Catalytic domain sequence
468 aa
DFVVVANRLPVDQERLPDGTIAWKRSPGGLVTALEPLLRRRRGAWVGWAGVVENDVDVQDEPIVQDELQLQPVRLSADDVAQYYEGFSNATLWPLYHDVIVRPIYHREWWDRYVDVNRRFAEATARAAARGGTVWVQDYQLQLVPKMLRAMRPDLTIGFFLHIPFPPVELFMQLPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGADTSRGTVGVRSRFGEVILGSRTIRVGAFPISIDSGALDQTARDRNIRRRSREIRAELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVESYQTLRNDIERQVGHINGEYAEVGHPVVHYLHRPVPRNELIAFFVASDVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALNQTEEAGRRRMRSMRRQVLAHDVDRWARSFLDALA
