Home/GT Families/GT20/otsA
otsA
Mycobacterium sp. (strain MCS) · Trehalose-6-phosphate synthase (EC 2.4.1.15; 2.4.1.347)
GT20Non-model organism · annotation 4–5Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT20 · CAZy entry |
|---|
| Gene symbol | otsA |
|---|
| Synonyms / alternate names | - Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
- Osmoregulatory trehalose synthesis protein A
|
|---|
| UniProt accession | Q1B321 |
|---|
| NCBI Gene ID | not curated |
|---|
| Source species | Mycobacterium sp. (strain MCS) |
|---|
| Taxonomic domain | Bacteria |
|---|
| UniProt annotation level | 4 |
|---|
Function and localisation
| Enzyme function | Trehalose-6-phosphate synthase (EC 2.4.1.15; 2.4.1.347) |
|---|
| Subcellular location | not curated |
|---|
Structure and mechanism
| Fold type | GT-B |
|---|
| Catalytic mechanism | Retaining |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | homotetramer |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | - ADP-alpha-D-glucose
- CDP-alpha-D-glucose
- GDP-alpha-D-glucose
- TDP-alpha-D-glucose
- UDP-alpha-D-glucose
|
|---|
| Donor CCD code(s) | ADQ, GDG, UPG |
|---|
| Acceptor substrate(s) | D-glucose 6-phosphate |
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
489 aa
MASEGDPGVGSGDSDFVVVANRLPIDMERLPDGSTSFKRSPGGLVTALEPLLRKRHGAWIGWAGIPDSAEDPIEDDGLQLYPVSLSADDVADYYEGFSNATLWPLYHDLIVKPIYHRKWWDRYVEVNRRFAEATARAAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIEGLLGADLVGFHLPGGAQNFLYLARRLTGANTSRATVGVRSRFGEVQVGFRTVKVGAFPISIDSDELDGKARNRAVRQRAREIRNELGNPRKILLGVDRLDYTKGINVRLEALSELLEDGRVDSHDTVFVQLATPSRERVQSYIEMREDIERQVGHINGEFGDVGHPIVHYLHRPIPRDELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLANPHHLEGVKDAIEAALNQDPEEGRRRMRALRRQVLAHDVDRWARAFLDALADTRAGAKPVRD
Catalytic domain sequence
464 aa
DFVVVANRLPIDMERLPDGSTSFKRSPGGLVTALEPLLRKRHGAWIGWAGIPDSAEDPIEDDGLQLYPVSLSADDVADYYEGFSNATLWPLYHDLIVKPIYHRKWWDRYVEVNRRFAEATARAAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIEGLLGADLVGFHLPGGAQNFLYLARRLTGANTSRATVGVRSRFGEVQVGFRTVKVGAFPISIDSDELDGKARNRAVRQRAREIRNELGNPRKILLGVDRLDYTKGINVRLEALSELLEDGRVDSHDTVFVQLATPSRERVQSYIEMREDIERQVGHINGEFGDVGHPIVHYLHRPIPRDELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLANPHHLEGVKDAIEAALNQDPEEGRRRMRALRRQVLAHDVDRWARAFLDALA
