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GlcT
Drosophila melanogaster · ceramide glucosyltransferase (EC 2.4.1.80)
GT21Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT21 · CAZy entry |
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| Gene symbol | GlcT |
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| Synonyms / alternate names | - dGlcCerT
- DGlcT-1
- Dmel\CG6437
- GlcT-1
- GlcT1
|
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| UniProt accession | Q9W297 |
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| NCBI Gene ID | 37516 |
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| Source species | Drosophila melanogaster |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | ceramide glucosyltransferase (EC 2.4.1.80) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-xylose |
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| Donor CCD code(s) | UDX |
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| Acceptor substrate(s) | - N-(9Z-octadecenoyl)-sphing-4-enine
- an N-acylsphing-4-enine
|
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
440 aa
MSHLPLPLYGFAAFFMVFWLGTWMVHVIAICYGRYKLHKKSCKLPTEAQPLPGVSILKPLMGVDPNLQHNLETFFTMDYPLYELLFCVEDKEDPAIQLVERLLAKYPLVDAALFVGGSDVGVNPKINNIHPGYMAAKYDFVMISDSGIKMKDDTLLDMVQNMSEKHALVHQMPFTCDRDGFAATFEKVFFGTVQSRIYLSADVLGINCHTGMSCLLRKAVIDQLGGLRAFGCYLAEDFFIARSVTRLGWKMRISNQPALQNSGLCDIGSFQARLIRWAKLRVAMVPTTILLEPLSECMILGAIAAWSASVLFSWDPLVFYLVHVLCWFLSDWLLLSIVQHGSMPFHKFEFVVGWLFRELTGPYLFLHALWNPAIRWRARTYKLHWGGVAYELNSLASDAANDPLAPQPQPAPTLEPAVVNAGTTGDTLICTGAKQRLLVS
Catalytic domain sequence
299 aa
VSILKPLMGVDPNLQHNLETFFTMDYPLYELLFCVEDKEDPAIQLVERLLAKYPLVDAALFVGGSDVGVNPKINNIHPGYMAAKYDFVMISDSGIKMKDDTLLDMVQNMSEKHALVHQMPFTCDRDGFAATFEKVFFGTVQSRIYLSADVLGINCHTGMSCLLRKAVIDQLGGLRAFGCYLAEDFFIARSVTRLGWKMRISNQPALQNSGLCDIGSFQARLIRWAKLRVAMVPTTILLEPLSECMILGAIAAWSASVLFSWDPLVFYLVHVLCWFLSDWLLLSIVQHGSMPFHKFEFVV
