Home/GT Families/GT29/PECUL_23A023017
PECUL_23A023017
Pelobates cultripes · CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC 2.4.3.2; 2.4.3.4; 2.4.3.6)
GT29Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT29 · CAZy entry |
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| Gene symbol | PECUL_23A023017 |
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| Synonyms / alternate names | - Alpha 2,3-sialyltransferase IV
- Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
- Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase
- N-acetyllactosaminide alpha-2,3-sialyltransferase
- ST3Gal IV
- Sialyltransferase 4C
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| UniProt accession | A0AAD1TAC1 |
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| NCBI Gene ID | not curated |
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| Source species | Pelobates cultripes |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC 2.4.3.2; 2.4.3.4; 2.4.3.6) |
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| Subcellular location | - Golgi apparatus membrane
- Golgi apparatus, Golgi stack membrane
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
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| Donor CCD code(s) | NCC |
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| Acceptor substrate(s) | - a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative
- a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative
- a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
- a ganglioside GA1 (d18:1(4E))
- a ganglioside GM1 (d18:1(4E))
- a ganglioside GT1c (d18:1(4E))
- a neolactoside nLc4Cer
- a neolactoside nLc4Cer(d18:1(4E))
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
289 aa
MGDVADKAAILISNYSRDHPVFLQLSDYFWVKNQTVYGLPYGTNGSEYLLMTFLALTNSYHVPPEIERGRLACRRCVVVGSGYRLRNSSLGEVINKYDIVIRLNNAPVHKYEKDVGNKTTMRFFYPESAHFNQHLDNNPDTLMVLVPYKPMDIVWMKIILNDEKRVRKGFWKMPPIIWEADLRNFRILNPYYMEVAGTKMLNPGQDSKKRIRVKPTTGMLAITFALHFCDLVHIAGFGYPASTNKNQSIHYYNKATLKNMGVKAHSINGEAEIIKKFIRHKLIQNLTYF
Catalytic domain sequence
245 aa
YGLPYGTNGSEYLLMTFLALTNSYHVPPEIERGRLACRRCVVVGSGYRLRNSSLGEVINKYDIVIRLNNAPVHKYEKDVGNKTTMRFFYPESAHFNQHLDNNPDTLMVLVPYKPMDIVWMKIILNDEKRVRKGFWKMPPIIWEADLRNFRILNPYYMEVAGTKMLNPGQDSKKRIRVKPTTGMLAITFALHFCDLVHIAGFGYPASTNKNQSIHYYNKATLKNMGVKAHSINGEAEIIKKFIRHK
