Home/GT Families/GT29/PECUL_23A025023
PECUL_23A025023
Pelobates cultripes · Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC 2.4.3.7)
GT29Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT29 · CAZy entry |
|---|
| Gene symbol | PECUL_23A025023 |
|---|
| Synonyms / alternate names | - GalNAc alpha-2,6-sialyltransferase VI
- ST6GalNAc VI
- Sialyltransferase 7F
|
|---|
| UniProt accession | A0AAD1T1P4 |
|---|
| NCBI Gene ID | not curated |
|---|
| Source species | Pelobates cultripes |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 4 |
|---|
Function and localisation
| Enzyme function | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC 2.4.3.7) |
|---|
| Subcellular location | Golgi apparatus membrane |
|---|
Structure and mechanism
| Fold type | GT-A |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
|---|
| Donor CCD code(s) | NCC |
|---|
| Acceptor substrate(s) | - 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein]
- 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein]
- N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
- a ganglioside GD1a (d18:1(4E))
- a ganglioside GM1b (d18:1(4E))
- a ganglioside GT1b (d18:1(4E))
- a globoside MSGG
|
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
643 aa
MLRSAPALWITVQCKHEPVLSGPGLSAVHTCELSVWVKMKILARVCAGCLLLFIILWLCWINIKEHADRPPPFVTRALQLWGYSRLPDGEPLVRSSCGTCAVVSSSGQMLGSGLGHEIDQAECILRMNIAPTVGYESDVGSRSTLRVVSHTSVPLLLRNQTYFFQQSQDTVYVIWGPPRQMNIDSGITYRALLQAKGRYPRVQIYTLTQNMMVHCDQIFQNETGKNRAMSGAFLSTGWFTMILAMELCEEISVYGMVSENYCREHSHPPVPYHYYEKGRLDECSMYMIHERALRGAHRFITEKAIFSRWVVTHSDHLCQRLVFPDRMQPEQQPEYQGERHGTAGRTAALLLIFALVTFLIILGSNNTDEPFNYRDLKIKHHNPPNIRKWRLQDGYISVSGNKTLHPKCNSCVIVTSSSHLLNTGLGYTIDQSECTIRMNDAPTTGYEKDVGNKTTFRVVAHSSVYRVLRRPQEFLSRAPGQTLIFWGPPSKMQQNSKTNLYHIIQRASSAFPNVSAFIVSPRNMGRFDDLFRAETGRDREKSHSWLSTGWFTMVIAVELCNNVHVYGMVPPNYCSRRQRKMPYHYYEPRGSDECTTYIQNERGRRGNHHRFITEKLVFARWAPVYNITFSHPQWFSSSETGFN
Catalytic domain sequence
503 aa
GEPLVRSSCGTCAVVSSSGQMLGSGLGHEIDQAECILRMNIAPTVGYESDVGSRSTLRVVSHTSVPLLLRNQTYFFQQSQDTVYVIWGPPRQMNIDSGITYRALLQAKGRYPRVQIYTLTQNMMVHCDQIFQNETGKNRAMSGAFLSTGWFTMILAMELCEEISVYGMVSENYCREHSHPPVPYHYYEKGRLDECSMYMIHERALRGAHRFITEKAIFSRWVVTHSDHLCQRLVFPDRMQPEQQPEYQGERHGTAGRTAALLLIFALVTFLIILGSNNTDEPFNYRDLKIKHHNPPNIRKWRLQDGYISVSGNKTLHPKCNSCVIVTSSSHLLNTGLGYTIDQSECTIRMNDAPTTGYEKDVGNKTTFRVVAHSSVYRVLRRPQEFLSRAPGQTLIFWGPPSKMQQNSKTNLYHIIQRASSAFPNVSAFIVSPRNMGRFDDLFRAETGRDREKSHSWLSTGWFTMVIAVELCNNVHVYGMVPPNYCSRRQRKMPYHYYEPRGS
