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Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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ST8SIA3

Homo sapiens · Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (EC 2.4.3.-; 2.4.3.8)

GT29Model organism · annotation ≥ 4Fold GT-AInverting5 PDB structure(s)

External resources

UniProt O43173AlphaFold modelInterPro domainsNCBI Gene 51046CAZy GT29PDB 5BO6PDB 5BO7PDB 5BO8PDB 5BO9PDB 5CXY

Identification and annotation

CAZy familyGT29 · CAZy entry
Gene symbolST8SIA3
Synonyms / alternate names
  • SIAT8C
  • Alpha-2,8-sialyltransferase 8C
  • Alpha-2,8-sialyltransferase III
  • Ganglioside GD3 synthase ST8SIA3
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
  • Sia-a2,3-Gal-b1,4-Glc-NAc-R:a2,8-sialyltransferase
  • Sialyltransferase 8C
  • Sialyltransferase St8Sia III
UniProt accessionO43173
NCBI Gene ID51046
Source speciesHomo sapiens
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme functionAlpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (EC 2.4.3.-; 2.4.3.8)
Subcellular locationGolgi apparatus membrane

Structure and mechanism

Fold typeGT-A
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statehomodimer
PDB structures5BO6, 5BO7, 5BO8, 5BO9, 5CXY

Donor and acceptor specificity

Sugar nucleotide donorCMP-N-acetyl-beta-neuraminate
Donor CCD code(s)NCC
Acceptor substrate(s)
  • [N-acetyl-alpha-D-neuraminosyl-(2->8)](n)
  • alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc
  • a ganglioside GM3 (d18:1(4E))
  • a ganglioside GM3
  • an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative
  • an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

380 aa 
MRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQFALKFLDPSFVPITNSLTQELQEKPSKWKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA

Catalytic domain sequence

254 aa 
TKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEG
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