Home/GT Families/GT29/ST8SIA4
ST8SIA4
Homo sapiens · CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-)
GT29Model organism · annotation ≥ 4Fold GT-AInverting3 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT29 · CAZy entry |
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| Gene symbol | ST8SIA4 |
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| Synonyms / alternate names | - PST
- PST1
- SIAT8D
- Alpha-2,8-sialyltransferase 8D
- Polysialyltransferase
- Polysialyltransferase-1
- Sialyltransferase 8D
- Sialyltransferase St8Sia IV
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| UniProt accession | Q92187 |
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| NCBI Gene ID | 7903 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) |
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| Subcellular location | - Golgi apparatus membrane
- Secreted
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | 5Y22, 5Y3U, 6AHZ |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
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| Donor CCD code(s) | NCC |
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| Acceptor substrate(s) | [N-acetyl-alpha-D-neuraminosyl-(2->8)](n) |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
359 aa
MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
Catalytic domain sequence
247 aa
SFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRG
