Home/GT Families/GT30/kdtA
kdtA
Aquifex aeolicus (strain VF5) · 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12)
GT30Non-model organism · annotation 4–5Fold GT-BInverting2 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT30 · CAZy entry |
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| Gene symbol | kdtA |
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| Synonyms / alternate names | - Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
- Monofunctional Kdo transferase
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| UniProt accession | O66663 |
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| NCBI Gene ID | not curated |
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| Source species | Aquifex aeolicus (strain VF5) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | 2XCI, 2XCU |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-3-deoxy-beta-D-manno-octulosonate |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | lipid IVA (E. coli) |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
353 aa
MQFEVLKRFFPKESLKNCKGALWVHTASIGEFNTFLPILKELKREHRILLTYFSPRAREYLKTKSDFYDCLHPLPLDNPFSVKRFEELSKPKALIVVEREFWPSLIIFTKVPKILVNAYAKGSLIEKILSKKFDLIIMRTQEDVEKFKTFGAKRVFSCGNLKFICQKGKGIKLKGEFIVAGSIHTGEVEIILKAFKEIKKTYSSLKLILVPRHIENAKIFEKKARDFGFKTSFFENLEGDVILVDRFGILKELYPVGKIAIVGGTFVNIGGHNLLEPTCWGIPVIYGPYTHKVNDLKEFLEKEGAGFEVKNETELVTKLTELLSVKKEIKVEEKSREIKGCYLEKLREFLRGL
Catalytic domain sequence
156 aa
RFFPKESLKNCKGALWVHTASIGEFNTFLPILKELKREHRILLTYFSPRAREYLKTKSDFYDCLHPLPLDNPFSVKRFEELSKPKALIVVEREFWPSLIIFTKVPKILVNAYAKGSLIEKILSKKFDLIIMRTQEDVEKFKTFGAKRVFSCGNLKF
