Home/GT Families/GT30/waaA
waaA
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) · 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12; 2.4.99.13)
GT30Model organism · annotation ≥ 4Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT30 · CAZy entry |
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| Gene symbol | waaA |
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| Synonyms / alternate names | - kdtA
- Bifunctional Kdo transferase
- Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
- Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
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| UniProt accession | P0AC76 |
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| NCBI Gene ID | 93778346 |
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| Source species | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12; 2.4.99.13) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-3-deoxy-beta-D-manno-octulosonate |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | - lipid IVA (E. coli)
- alpha-Kdo-(2->6)-lipid IVA (E. coli)
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
425 aa
MLELLYTALLYLIQPLIWIRLWVRGRKAPAYRKRWGERYGFYRHPLKPGGIMLHSVSVGETLAAIPLVRALRHRYPDLPITVTTMTPTGSERVQSAFGKDVQHVYLPYDLPDALNRFLNKVDPKLVLIMETELWPNLIAALHKRKIPLVIANARLSARSAAGYAKLGKFVRRLLRRITLIAAQNEEDGARFVALGAKNNQVTVTGSLKFDISVTPQLAAKAVTLRRQWAPHRPVWIATSTHEGEESVVIAAHQALLQQFPNLLLILVPRHPERFPDAINLVRQAGLSYITRSSGEVPSTSTQVVVGDTMGELMLLYGIADLAFVGGSLVERGGHNPLEAAAHAIPVLMGPHTFNFKDICARLEQASGLITVTDATTLAKEVSSLLTDADYRSFYGRHAVEVLYQNQGALQRLLQLLEPYLPPKTH
Catalytic domain sequence
91 aa
QVVVGDTMGELMLLYGIADLAFVGGSLVERGGHNPLEAAAHAIPVLMGPHTFNFKDICARLEQASGLITVTDATTLAKEVSSLLTDADYRS
