Home/GT Families/GT31/B3GALT4
B3GALT4
Canis lupus familiaris · Beta-1,3-galactosyltransferase 4 (EC 2.4.1.62)
GT31Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT31 · CAZy entry |
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| Gene symbol | B3GALT4 |
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| Synonyms / alternate names | - Gal-T2
- Ganglioside galactosyltransferase
- UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
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| UniProt accession | Q5TJE8 |
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| NCBI Gene ID | 481737 |
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| Source species | Canis lupus familiaris |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Beta-1,3-galactosyltransferase 4 (EC 2.4.1.62) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
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| Donor CCD code(s) | GDU |
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| Acceptor substrate(s) | - a ganglioside GM2 (d18:1(4E))
- a ganglioside GM2
- a ganglioside GD2 (d18:1(4E))
- a ganglioside GA2 (d18:1(4E))
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
383 aa
MPLSLFRRLLLAALLLVIIWTLFGPSGIGEELLSLSLASLSPAPASPGPPLALPRLLIPNEKACGGPGSPPFLLILVCTAPENLNQRNAIRASWGGLREAQGFRVQILFLLGEPSLWHPTKEPHDIDLVREAAAQGDILQAAFRDSYRNLTLKTLSGLNWADKHCSMARYILKTDDDVFVNVPELVSELIRRGGHWEQWEKGKEPPRAVKAGDKEWEERPILKSQPMPLLYLGRVHWRVHPSRTPGSKHQISEEQWPPTWGPFPPYASGTGYVLSASAVQLILKVASRAPPLPLEDVFVGVSARRGGLTPTHCVKLAGATHYPLDRCCYGKFLLTSHKLDPWKMQEAWKLVGGSDGERTAPFCSWLQEVLGILRCRVIAWLHS
Catalytic domain sequence
229 aa
NQRNAIRASWGGLREAQGFRVQILFLLGEPSLWHPTKEPHDIDLVREAAAQGDILQAAFRDSYRNLTLKTLSGLNWADKHCSMARYILKTDDDVFVNVPELVSELIRRGGHWEQWEKGKEPPRAVKAGDKEWEERPILKSQPMPLLYLGRVHWRVHPSRTPGSKHQISEEQWPPTWGPFPPYASGTGYVLSASAVQLILKVASRAPPLPLEDVFVGVSARRGGLTPTHC
