B3GALT5 (GT31)

B3GALT5

Homo sapiens · Beta-1,3-galactosyltransferase 5 (EC 2.4.1.-)

GT31Model organism · annotation ≥ 4Fold GT-AInverting8 PDB structure(s)

External resources

UniProt Q9Y2C3 AlphaFold model InterPro domains NCBI Gene 10317 CAZy GT31 PDB 8ZWP PDB 8ZWR PDB 8ZWW PDB 8ZWY PDB 8ZX2 PDB 8ZX3 PDB 8ZX8 PDB 8ZX9

Identification and annotation

CAZy family	GT31 · CAZy entry
Gene symbol	B3GALT5
Synonyms / alternate names	Beta-3-Gx-T5 UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
UniProt accession	`Q9Y2C3`
NCBI Gene ID	`10317`
Source species	Homo sapiens
Taxonomic domain	Eukaryota
UniProt annotation level	5

Function and localisation

Enzyme function	Beta-1,3-galactosyltransferase 5 (EC 2.4.1.-)
Subcellular location	Golgi apparatus membrane

Structure and mechanism

Fold type	GT-A
Catalytic mechanism	Inverting
Cation dependence	Yes (Mn2+)
Oligomeric state	not curated
PDB structures	`8ZWP`, `8ZWR`, `8ZWW`, `8ZWY`, `8ZX2`, `8ZX3`, `8ZX8`, `8ZX9`

Donor and acceptor specificity

Sugar nucleotide donor	UDP-alpha-D-galactose
Donor CCD code(s)	`GDU`
Acceptor substrate(s)	a globoside Gb4Cer (d18:1(4E))
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

310 aa

MAFPKMRLMYICLLVLGALCLYFSMYSLNPFKEQSFVYKKDGNFLKLPDTDCRQTPPFLVLLVTSSHKQLAERMAIRQTWGKERMVKGKQLKTFFLLGTTSSAAETKEVDQESQRHGDIIQKDFLDVYYNLTLKTMMGIEWVHRFCPQAAFVMKTDSDMFINVDYLTELLLKKNRTTRFFTGFLKLNEFPIRQPFSKWFVSKSEYPWDRYPPFCSGTGYVFSGDVASQVYNVSKSVPYIKLEDVFVGLCLERLNIRLEELHSQPTFFPGGLRFSVCLFRRIVACHFIKPRTLLDYWQALENSRGEDCPPV

Catalytic domain sequence

189 aa

ERMAIRQTWGKERMVKGKQLKTFFLLGTTSSAAETKEVDQESQRHGDIIQKDFLDVYYNLTLKTMMGIEWVHRFCPQAAFVMKTDSDMFINVDYLTELLLKKNRTTRFFTGFLKLNEFPIRQPFSKWFVSKSEYPWDRYPPFCSGTGYVFSGDVASQVYNVSKSVPYIKLEDVFVGLCLERLNIRLEEL