Home/GT Families/GT31/sqv-5
sqv-5
Caenorhabditis elegans · Chondroitin sulfate synthase sqv-5 (EC 2.4.1.174; 2.4.1.175; 2.4.1.226)
GT31Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT31 · CAZy entry |
|---|
| Gene symbol | sqv-5 |
|---|
| Synonyms / alternate names | - Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase 1
- Glucuronylgalactosylproteoglycan 4-beta-N- acetylgalactosaminyltransferase
- N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1
- Squashed vulva protein 5
|
|---|
| UniProt accession | Q7Z1Z1 |
|---|
| NCBI Gene ID | 172851 |
|---|
| Source species | Caenorhabditis elegans |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | Chondroitin sulfate synthase sqv-5 (EC 2.4.1.174; 2.4.1.175; 2.4.1.226) |
|---|
| Subcellular location | - Golgi apparatus
- Golgi stack membrane
|
|---|
Structure and mechanism
| Fold type | GT-A |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | Yes (Mn2+) |
|---|
| Oligomeric state | Interacts with mig-22 |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-N-acetyl-alpha-D-galactosamine
- UDP-alpha-D-glucuronate
|
|---|
| Donor CCD code(s) | UD2, UGA |
|---|
| Acceptor substrate(s) | - 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
- 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
- 3-O-{beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]
- 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
- 3-O-{[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]
|
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
736 aa
MRVFQRSTCRMPVSRATVTILLGILFGFSITYYLTALKSLTNPIICGPEQQIGGFDYLDVISQRADADVFTRSQSLPGHRRGLILVAIMTAAKYVDTRAYNVWKTWAQHIPGRVLIFVAEGTESVHEDMPLIRLKGVDDTYPPQKKSFAMVKWLAENMADEYDWFLRADDDLYIRGEELALFLRSVDSSKAHIIGQAGLGNSAEYGLLALGSTDNYCMGGPGIVMSRDTLLKVSPHLESCLQHMLTSHEDVELGRCIRKHVGVACTWNYEMQKLFHNNQSAIKESYAKNMKELKDAITLHPIKDPAVMRKVHLRNREIKLREARAKRSLLSSELSTAKAQTLVRMTPNRTNDLTPWEYINNNKILFCADRVNCPRHTVDLSIRTEMADTITQLFDEFNTNARQRGRVLQFQSLQYGYMRVEPTKGVDYVLDMLLWFKKFRPPNRTTISVRRHAYVQQTFGKLRSLSEGVFRSNMRANSTLIEDPTLHMIMPLRGRAAIFARFAQHLKSICARGGDDLAVSLTIVLYSSEDEMENRETIEMLRASFIPVTVIEMGDVSFSRGVALMRGAETLPANALLFFTDVDMLFTCDALKRIKSNTILNAQIYFPIVFSEFSHESWSENDKLLADAFHYGRGRGYFRHFGYGLAAMYKADLMDVGGFDTKIEGWGKEDVDLFEKAIKNGRLRVIRVPEPGLVHIYHPIHCDENMPTAQKDMCHGSKAASLASIDTLVEQIAQYT
Catalytic domain sequence
493 aa
HLESCLQHMLTSHEDVELGRCIRKHVGVACTWNYEMQKLFHNNQSAIKESYAKNMKELKDAITLHPIKDPAVMRKVHLRNREIKLREARAKRSLLSSELSTAKAQTLVRMTPNRTNDLTPWEYINNNKILFCADRVNCPRHTVDLSIRTEMADTITQLFDEFNTNARQRGRVLQFQSLQYGYMRVEPTKGVDYVLDMLLWFKKFRPPNRTTISVRRHAYVQQTFGKLRSLSEGVFRSNMRANSTLIEDPTLHMIMPLRGRAAIFARFAQHLKSICARGGDDLAVSLTIVLYSSEDEMENRETIEMLRASFIPVTVIEMGDVSFSRGVALMRGAETLPANALLFFTDVDMLFTCDALKRIKSNTILNAQIYFPIVFSEFSHESWSENDKLLADAFHYGRGRGYFRHFGYGLAAMYKADLMDVGGFDTKIEGWGKEDVDLFEKAIKNGRLRVIRVPEPGLVHIYHPIHCDENMPTAQKDMCHGSKAASLASIDTL
