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A4galt
Mus musculus · Lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228)
GT32Non-model organism · annotation 4–5Fold GT-ARetaining
External resources
Identification and annotation
| CAZy family | GT32 · CAZy entry |
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| Gene symbol | A4galt |
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| Synonyms / alternate names | - Alpha-1,4-N-acetylglucosaminyltransferase
- Alpha-1,4-galactosyltransferase
- Alpha4Gal-T1
- Globotriaosylceramide synthase
- UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
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| UniProt accession | Q67BJ4 |
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| NCBI Gene ID | 239559 |
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| Source species | Mus musculus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
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| Donor CCD code(s) | GDU |
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| Acceptor substrate(s) | - a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
- a beta-D-Gal-(1<->1')-ceramide
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
359 aa
MGISCSHLEETMSKPPDCLLRMLRGTPRQRVFTFFIISFKFMFLISILIYWHTVGAPKDQREYSLPVDFSCPQLAFPRVSAPGNIFFLETSDRTSPNFLFMCSVESAARAHPESQVVVLMKGLPRDTTAQPRNLGISLLSCFPNVWIRPLDLQELFEDTPLAAWYSEARHRWEPYQLPVLSDASRIALLWKFGGIYLDTDFIVLKNLLNLTNTLGIQSRYVLNGAFLAFERKHEFLALCLHDFVANYNGWIWGHQGPQLLTRVFKKWCSIQSLEKSHACRGVTALPPEAFYPIPWQNWKKYFEDISPEELTQLLNATYAVHVWNKKSQGTHLEATSKALLAQLHARYCPTTHRAMKMYL
Catalytic domain sequence
127 aa
AFERKHEFLALCLHDFVANYNGWIWGHQGPQLLTRVFKKWCSIQSLEKSHACRGVTALPPEAFYPIPWQNWKKYFEDISPEELTQLLNATYAVHVWNKKSQGTHLEATSKALLAQLHARYCPTTHRA
