Home/GT Families/GT32/CSH1
CSH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) · Mannosyl phosphorylinositol ceramide synthase CSH1 (EC 2.4.1.370)
GT32Model organism · annotation ≥ 4Fold GT-ARetaining
External resources
Identification and annotation
| CAZy family | GT32 · CAZy entry |
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| Gene symbol | CSH1 |
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| Synonyms / alternate names | CSG1/SUR1 homolog 1 |
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| UniProt accession | P38287 |
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| NCBI Gene ID | 852458 |
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| Source species | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Mannosyl phosphorylinositol ceramide synthase CSH1 (EC 2.4.1.370) |
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| Subcellular location | Vacuole membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | heterodimer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-alpha-D-mannose |
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| Donor CCD code(s) | GDD |
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| Acceptor substrate(s) | a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
376 aa
MKKELKILIIANIALLISIIHYTFDLLTLCIDDTSKDALTDEQLNPPNGFNSTFYESPPQLIPKIIHQTYKTNDIPEQWVKGRQKCIDLHPDYTYILWTDEMSDTFIKQEYPWFLDTFRSYEYPIERADAIRYFILSHYGGIYIDLDDGCERRLDPLLKVPAFLRKTSPTGVSNDVMGSVPRHPFFLKVIKSLKHYKKNWYIPYMTIMGSTGPLFISVVWKQYKRWSNTAENGAVRILQPADYKMHNNSFFSISKGSSWHTGDANFMKTLENHILSCVVTGFIFGFFILYGEFTFYTWLCSGPFNNKRYYIQWLSDKFKLHKWKLTSSYKNKEKRRNPTRHEYNSRGKRLRKDSNIPYDSVFLDIEKNHAKFTDLT
Catalytic domain sequence
84 aa
PEQWVKGRQKCIDLHPDYTYILWTDEMSDTFIKQEYPWFLDTFRSYEYPIERADAIRYFILSHYGGIYIDLDDGCERRLDPLLK
