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alpha4GT2
Drosophila melanogaster · Alpha1,4-N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-)
GT32Model organism · annotation ≥ 4Fold GT-ARetaining
External resources
Identification and annotation
| CAZy family | GT32 · CAZy entry |
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| Gene symbol | alpha4GT2 |
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| Synonyms / alternate names | - Alpha1,4-galactosyltransferase 2
- UDP-GalNAc:betaGalNAc alpha1-4GalNAc-transferase
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| UniProt accession | Q9VBL5 |
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| NCBI Gene ID | 43124 |
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| Source species | Drosophila melanogaster |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Alpha1,4-N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-) |
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| Subcellular location | Membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-galactosamine |
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| Donor CCD code(s) | UD2 |
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| Acceptor substrate(s) | - a beta-D-GalNAc-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Man-(1->4)-beta-D-Glc-(1<->1)-Cer
- an N-acetyl-beta-D-galactosaminyl derivative
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
395 aa
MKVSRTLIVVGSLLLILSIVLTYKWIAYNHAYPKAQTELTNSTKKANLIDSKAKNKKHVQNSLAKKAAKSVANQSKFKLDKVSKKIPVIPLLDVLKAKKQPSRGQNIFFHETTNFKRIEKSSVVQLTAREACAIESAALHNPGLTVFVLFAGATHRPSSGDPLIRALHNYKNIRLRHLNLWRYAAGTPIAKWLKSGKLFKSKFLFPHVSDLLRYVSLYKYGGLYLDLDVVVQQNLEKLPPNFTGAESNISVACGVMKMSPGGLGHKIATMCLRDLEANYNANKWGTNGPGVITRVVKKQCNTDNIKSVINNPKRCNGFKVFDANAFYAISWLQWKDFFQPNRHNVTMKRVSKSPVIHVWNKFSKGWKVKTKSNCAYTTLAKIHCPRSFAAAGELF
Catalytic domain sequence
128 aa
LGHKIATMCLRDLEANYNANKWGTNGPGVITRVVKKQCNTDNIKSVINNPKRCNGFKVFDANAFYAISWLQWKDFFQPNRHNVTMKRVSKSPVIHVWNKFSKGWKVKTKSNCAYTTLAKIHCPRSFAA
