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ALG2
Candida albicans (strain SC5314 / ATCC MYA-2876) · Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132; 2.4.1.257)
GT4Non-model organism · annotation 4–5Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT4 · CAZy entry |
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| Gene symbol | ALG2 |
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| Synonyms / alternate names | - Asparagine-linked glycosylation protein 2
- GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
- GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase
- GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
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| UniProt accession | Q59LF2 |
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| NCBI Gene ID | 3647832 |
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| Source species | Candida albicans (strain SC5314 / ATCC MYA-2876) |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132; 2.4.1.257) |
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| Subcellular location | Endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-alpha-D-mannose |
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| Donor CCD code(s) | GDD |
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| Acceptor substrate(s) | - a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol
- an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
443 aa
MSKRQENKKIAFIHPDLGIGGAERLVVDAAVGLQDFGHDIIIYTSHCDLTHCFEEVSSGQLKVSVHGDSLPTNLFGKLHIFFAILRQFYLVCWLIFTGTIKNYDYFIVDQLSFCIPLLKMFCNSNCQVLFYCHFPDQLLVRRTSFLKKLYRVPFDAIEEYTTGSSDQIVVNSNFTKQIFHDTFKKLNHIDPQVVYPCVDTETIVDTNASSNSEVSKFFKDSPFFLSINRFERSKNIELAIKSFARMNKLMVTKAIKSFARMNKLMVTNKKPRLVIAGGYDSRVAENVEYLAELSTLCDELNLINFTIRGKLIMMPPSVDVLFLPSISTQLKNSLIQQTELLLYTPPREHFGIVPLEAMLAKTPVLAINFGGPLETVVNYNGNNLDEATGYTETGDFTKWSKIIMKHYNLDESTKIKLGENGRNRVINKFSRKKLAQSLDNILN
Catalytic domain sequence
431 aa
KKIAFIHPDLGIGGAERLVVDAAVGLQDFGHDIIIYTSHCDLTHCFEEVSSGQLKVSVHGDSLPTNLFGKLHIFFAILRQFYLVCWLIFTGTIKNYDYFIVDQLSFCIPLLKMFCNSNCQVLFYCHFPDQLLVRRTSFLKKLYRVPFDAIEEYTTGSSDQIVVNSNFTKQIFHDTFKKLNHIDPQVVYPCVDTETIVDTNASSNSEVSKFFKDSPFFLSINRFERSKNIELAIKSFARMNKLMVTKAIKSFARMNKLMVTNKKPRLVIAGGYDSRVAENVEYLAELSTLCDELNLINFTIRGKLIMMPPSVDVLFLPSISTQLKNSLIQQTELLLYTPPREHFGIVPLEAMLAKTPVLAINFGGPLETVVNYNGNNLDEATGYTETGDFTKWSKIIMKHYNLDESTKIKLGENGRNRVINKFSRKKLAQSL
