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alg11
Schizosaccharomyces pombe (strain 972 / ATCC 24843) · GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131)
GT4Non-model organism · annotation 4–5Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT4 · CAZy entry |
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| Gene symbol | alg11 |
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| Synonyms / alternate names | - gmd3
- Alpha-1,2-mannosyltransferase alg11
- Asparagine-linked glycosylation protein 11
- Galactomannan deficiency protein 3
- Glycolipid 2-alpha-mannosyltransferase
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| UniProt accession | O74878 |
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| NCBI Gene ID | 2539054 |
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| Source species | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) |
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| Subcellular location | Endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | 2 GDP-alpha-D-mannose |
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| Donor CCD code(s) | GDD |
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| Acceptor substrate(s) | - an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans
- poly-cis-dolichol
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
471 aa
MITTLAIALFIAVVAIHSHIRRKICKEIGIRLIKKIAPVKASLYKQVGVEPKLARTVGFFHPYCNAGGGGERVLWTAVKSVQTEFPNVISVVYTGDNVSKAEILRRVKNTFEIDLDSSKIVFVYLKLRFLVSATTWHRFTLLGQSLGSMILGFEAIYRFAPDIFIDTMGYAFTFCVVKSFQNIPVGAYVHYPTISTDMLKSLKQVSLLAKVKMAYWRWFAQLYSDAGSHADYVMTNSSWTRNHIASLWGKDIQLSVVFPPCNTSELEKIDINRKREPTLLYLAQYRPEKNHENVLRSFALYFEQHPDSPAKLLLVGSVRGEEDMCFVNHLKTLATELNLQSKVKFVVDAPWPKVVEYLGTCSIGVNYMWNEHFGIGVVEYMAAGLIPVVNNSGGPKFDIVIPWIGKPTGFHASTISEYAEAYHKALTLSPQEQLEMRINARSACARFGEHVFMRDFGNVFAKLLREDYSRT
Catalytic domain sequence
401 aa
RTVGFFHPYCNAGGGGERVLWTAVKSVQTEFPNVISVVYTGDNVSKAEILRRVKNTFEIDLDSSKIVFVYLKLRFLVSATTWHRFTLLGQSLGSMILGFEAIYRFAPDIFIDTMGYAFTFCVVKSFQNIPVGAYVHYPTISTDMLKSLKQVSLLAKVKMAYWRWFAQLYSDAGSHADYVMTNSSWTRNHIASLWGKDIQLSVVFPPCNTSELEKIDINRKREPTLLYLAQYRPEKNHENVLRSFALYFEQHPDSPAKLLLVGSVRGEEDMCFVNHLKTLATELNLQSKVKFVVDAPWPKVVEYLGTCSIGVNYMWNEHFGIGVVEYMAAGLIPVVNNSGGPKFDIVIPWIGKPTGFHASTISEYAEAYHKALTLSPQEQLEMRINARSACARFGEHVFMRD
