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kanE
Streptomyces kanamyceticus · Alpha-D-kanosaminyltransferase (EC 2.4.1.301)
GT4Non-model organism · annotation 4–5Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT4 · CAZy entry |
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| Gene symbol | kanE |
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| Synonyms / alternate names | - 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
- Glycosyltransferase KanE
- Kanamycin biosynthesis protein E
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| UniProt accession | Q65CC7 |
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| NCBI Gene ID | not curated |
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| Source species | Streptomyces kanamyceticus |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Alpha-D-kanosaminyltransferase (EC 2.4.1.301) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-kanosamine |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | - 2'-deamino-2'-hydroxyneamine
- neamine
- paromamine
- 2'-deamino-2'-hydroxyparomamine
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
386 aa
MHLLVRALVEEMAGRGVPHRVLTMSPPKVPKDIRIGQRIKVHARRLPVLPIPSDLEGYFGLVGAWAKGSLLWVLRNRKRLRREIGARVHAHCDGSGAAAFYPYLMSRILGVPLVVQIHSSRYLSQHPTTLFERVTDPIAKWAERHAVRKAAAVLMLTDRARDEMRRKAQLPAERVHRLAYLASDQFKDADTEARRAELRERYGLDDRPIVLYVGRIAAEKGVEYYIEAAAELTRRGRDCQFVIAGDGPARPDLEKLIGARGLRDRVTITGFMSHEFIPSMISLGELVVLPSRYEELGIVILECMTMRRPLVAHDVNGVNKLIEDGTTGIVVPPFRTPEMADAVERLLDDPELRERMAENAAPLPAAKYSLSAAGDQLAGIYREIGL
Catalytic domain sequence
175 aa
VRALVEEMAGRGVPHRVLTMSPPKVPKDIRIGQRIKVHARRLPVLPIPSDLEGYFGLVGAWAKGSLLWVLRNRKRLRREIGARVHAHCDGSGAAAFYPYLMSRILGVPLVVQIHSSRYLSQHPTTLFERVTDPIAKWAERHAVRKAAAVLMLTDRARDEMRRKAQLPAERVHRLA
