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pimA
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) · Phosphatidyl-myo-inositol mannosyltransferase (EC 2.4.1.345)
GT4Non-model organism · annotation 4–5Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT4 · CAZy entry |
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| Gene symbol | pimA |
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| Synonyms / alternate names | - Alpha-mannosyltransferase
- GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase
- Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase
- Phosphatidylinositol alpha-mannosyltransferase
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| UniProt accession | P9WMZ5 |
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| NCBI Gene ID | 45426613; 888627 |
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| Source species | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Phosphatidyl-myo-inositol mannosyltransferase (EC 2.4.1.345) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mg2+) |
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| Oligomeric state | monomer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-alpha-D-mannose |
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| Donor CCD code(s) | GDD |
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| Acceptor substrate(s) | - a 1
- 2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
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| Acceptor CCD / GlycoCT | INS Verified PDB CCD code |
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Protein sequences
Full protein sequence
378 aa
MRIGMICPYSFDVPGGVQSHVLQLAEVMRTRGHLVSVLAPASPHAALPDYFVSGGRAVPIPYNGSVARLRFGPATHRKVKKWLAHGDFDVLHLHEPNAPSLSMLALNIAEGPIVATFHTSTTKSLTLTVFQGILRPMHEKIVGRIAVSDLARRWQMEALGSDAVEIPNGVDVDSFASAARLDGYPRQGKTVLFLGRYDEPRKGMAVLLDALPKVVQRFPDVQLLIVGHGDADQLRGQAGRLAAHLRFLGQVDDAGKASAMRSADVYCAPNTGGESFGIVLVEAMAAGTAVVASDLDAFRRVLRDGEVGHLVPVDPPDLQAAALADGLIAVLENDVLRERYVAAGNAAVRRYDWSVVASQIMRVYETVAGSGAKVQVAS
Catalytic domain sequence
364 aa
RIGMICPYSFDVPGGVQSHVLQLAEVMRTRGHLVSVLAPASPHAALPDYFVSGGRAVPIPYNGSVARLRFGPATHRKVKKWLAHGDFDVLHLHEPNAPSLSMLALNIAEGPIVATFHTSTTKSLTLTVFQGILRPMHEKIVGRIAVSDLARRWQMEALGSDAVEIPNGVDVDSFASAARLDGYPRQGKTVLFLGRYDEPRKGMAVLLDALPKVVQRFPDVQLLIVGHGDADQLRGQAGRLAAHLRFLGQVDDAGKASAMRSADVYCAPNTGGESFGIVLVEAMAAGTAVVASDLDAFRRVLRDGEVGHLVPVDPPDLQAAALADGLIAVLENDVLRERYVAAGNAAVRRYDWSVVASQIMRVYE
