GT-CORE (public beta v1)

Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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wbdA

Escherichia coli · Serotype-specific mannosyltransferase WbdA (EC 2.4.1.371)

GT4Model organism · annotation ≥ 4Fold GT-BRetaining

External resources

UniProt Q47593AlphaFold modelInterPro domainsCAZy GT4

Identification and annotation

CAZy familyGT4 · CAZy entry
Gene symbolwbdA
Synonyms / alternate names
  • mtfA
  • Bifunctional alpha-(1->2), alpha-(1->3)-mannosyltransferase
  • O-antigen chain mannosyltransferase A
  • Polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase
UniProt accessionQ47593
NCBI Gene IDnot curated
Source speciesEscherichia coli
Taxonomic domainBacteria
UniProt annotation level4

Function and localisation

Enzyme functionSerotype-specific mannosyltransferase WbdA (EC 2.4.1.371)
Subcellular locationnot curated

Structure and mechanism

Fold typeGT-B
Catalytic mechanismRetaining
Cation dependenceNo
Oligomeric statemonomer
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donor2 GDP-alpha-D-mannose
Donor CCD code(s)GDD
Acceptor substrate(s)
  • [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate
  • alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

815 aa 
MSRAIIENAGEHRVSILINGMYPIDNINDVKMAYRDLLTDEDMFIFSAVAPTAYRHIENHGRSKAAQAARDIAIANIAPDIVYVISFFEGHSDSYTVSIPADNVPWKTVCVCHDLIPLLNKERYLGDPNFREFYMNKLAEFERADAIFAISQSAAQEVIEYTDIASDRVLNISSAVGEEFAVIDYSAERIQSLKDKYSLPDEFILSLAMIEPRKNIEALIHAYSLLPAELQQRYPMVLAYKVQPEQLERILRLAESYGLSRSQLIFTGFLTDDDLIALYNLCKLFVFPSLHEGFGLPPLEAMRCGAATLGSNITSLPEVIGWEDAMFNPHDVQDIRRVMEKALTDEAFYRELKAHALAQSAKFSWANTAHLAIEGFTRLLQSSQETDAGQAESVTASRLQMMQKIDALSEVDRLGLAWAVARNSFKRHTRKLLVDISVLAHDDAKTGIQRVSRSILSELLKSGVPGYEVSAVYYTPGECYRYANQYLSSHFPGEFGADEPVLFSKDDVLIATDLTAHLFPELVTQIDSMRAAGAFACFVVHDILPLRRPEWSIEGIQRDFPIWLSCLAEHADRLICVSASVAEDVKAWIAENRHWVKPNPLQTVSNFHLGADLDASVPSTGMPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWREGKDYNLFIVGKQGWNVDSLCEKLRHHPQLNKKLFWLQNISDEFLAELYARSRALIFASQGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEHAWYFSGEAPSDIAKAVEEWLALYEQNAHPRSENINWLTWKQSAEFLLKNLPIIAPAAKQ

Catalytic domain sequence

587 aa 
DEFILSLAMIEPRKNIEALIHAYSLLPAELQQRYPMVLAYKVQPEQLERILRLAESYGLSRSQLIFTGFLTDDDLIALYNLCKLFVFPSLHEGFGLPPLEAMRCGAATLGSNITSLPEVIGWEDAMFNPHDVQDIRRVMEKALTDEAFYRELKAHALAQSAKFSWANTAHLAIEGFTRLLQSSQETDAGQAESVTASRLQMMQKIDALSEVDRLGLAWAVARNSFKRHTRKLLVDISVLAHDDAKTGIQRVSRSILSELLKSGVPGYEVSAVYYTPGECYRYANQYLSSHFPGEFGADEPVLFSKDDVLIATDLTAHLFPELVTQIDSMRAAGAFACFVVHDILPLRRPEWSIEGIQRDFPIWLSCLAEHADRLICVSASVAEDVKAWIAENRHWVKPNPLQTVSNFHLGADLDASVPSTGMPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWREGKDYNLFIVGKQGWNVDSLCEKLRHHPQLNKKLFWLQNISDEFLAELYARSRALIFASQGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEHAWYFSGEAPSDIAKAVEEWLALYEQNAHPRS
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