Home/GT Families/GT44/tcdA
tcdA
Clostridium novyi · Toxin A (EC 3.4.22.-)
GT44Non-model organism · annotation 4–5Fold GT-ARetaining1 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT44 · CAZy entry |
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| Gene symbol | tcdA |
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| Synonyms / alternate names | toxA |
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| UniProt accession | Q46149 |
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| NCBI Gene ID | not curated |
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| Source species | Clostridium novyi |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Toxin A (EC 3.4.22.-) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mn2+, Mg2+) |
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| Oligomeric state | not curated |
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| PDB structures | 2VK9 |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | L-threonyl-[protein] |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
2178 aa
MLITREQLMKIASIPLKRKEPEYNLILDALENFNRDIEGTSVKEIYSKLSKLNELVDNYQTKYPSSGRNLALENFRDSLYSELRELIKNSRTSTIASKNLSFIWIGGPISDQSLEYYNMWKMFNKDYNIRLFYDKNSLLVNTLKTAIIQESSKVIIEQNQSNILDGTYGHNKFYSDRMKLIYRYKRELKMLYENMKQNNSVDDIIINFLSNYFKYDIGKLNNQKENNNNKMIAIGATDINTENILTNKLKSYYYQELIQTNNLAAASDILRIAILKKYGGVYCDLDFLPGVNLSLFNDISKPNGMDSNYWEAAIFEAIANEKKLMNNYPYKYMEQVPSEIKERILSFVRNHDINDLILPLGDIKISQLEILLSRLKAATGKKTFSNAFIISNNDSLTLNNLISQLENRYEILNSIIQEKFKICETYDSYINSVSELVLETTPKNLSMDGSSFYQQIIGYLSSGFKPEVNSTVFFSGPNIYSSATCDTYHFIKNTFDMLSSQNQEIFEASNNLYFSKTHDEFKSSWLLRSNIAEKEFQKLIKTYIGRTLNYEDGLNFNKWKRVTTSELLKVIEEVNSTKIYENYDLNMILQIQGDDISYESAVNVFGKNPNKSILIQGVDDFANVFYFENGIVQSDNINNILSRFNDIKKIKLTLIGHGENVFNPKLFGGKTVNDLYTNIIKPKLQHLLEREGVILKNKYLKINILGCYMFTPKVDINSTFVGKLFNKISRDLQPKGFSKNQLEISANKYAIRINREGKREVLDYFGKWVSNTDLIAEQISNKYVVYWNEVENTLSARVEQLNKVAEFAKDINSIIQTTNNQELKQSLVNTYADLITTLYSELLKEDIPFELDNIQIKERIILNEISRLHDFSNIILDFYQKNNISNNMIILFDSIIKEKDYYNVKLANKITGETSVIKTYSDSLWNFTNKYKKIVDDIKGIIVKDINGEFIKKADFEIEQNPSLLNSAMLMQLLIDYKPYTEILTNMNTSLKVQAYAQIFQLSIGAIQEATEIVTIISDALNANFNILSKLKVGSSVASVIIDGINLIAALTELKNVKTNFERKLIEAKVGMYSIGFILESSSLISGLLGATAVSEILGVISVPVAGILVGLPSLVNNILVLGEKYNQILDYFSKFYPIVGKNPFSIQDNIIIPYDDIAITELNFKYNKFKYGYAKISGLKVGLVTHIGENIDHYFSAPSLDHYIELSIYPALKLNDTNLPKGNVVLLPSGLNKVYKPEISAIAGANSQEGNGVEVLNLIRNYYVDSNGNTKFPWKYEAPFEYSFSYMRVEYFDTKVNVILDNENKTLIIPVLTIDEMRNKISYEILGDGGQYNVILPVNQTNINIVSNKNDIWNFDVSYIVKESKIEDNKFVLDGFINNIFSTLKVSNDGFKIGKQFISIKNTPRAINLSFKINNNIVIVSIYLNHEKSNSITIISSDLNDIKNNFDNLLDNINYIGLGSISDNTINCIVRNDEVYMEGKIFLNEKKLVFIQNELELHLYDSVNKDSQYLINNPINNVVKYKDGYIVEGTFLINSTENKYSLYIENNKIMLKGLYLESSVFKTIQDKIYSKEKVNDYILSLIKKFFTVNIQLCPFMIVSGVDENNRYLEYMLSTNNKWIINGGYWENDFNNYKIVDFEKCNVIVSGSNKLNSEGDLADTIDVLDKDLENLYIDSVIIIPKVYTKKIIIHPIPNNPQINIINTQSIHDKCHLIIDSVLTNNYHWESDGDDLIITNGLDINIRILQGLSFGFKYKNIYLKFSNYDELSLNDFLLQNYNVKGLYYINGELHYKNIPGDTFEYGWINIDSRWYFFDSINLIAKKGYQEIEGERYYFNPNTGVQESGVFLTPNGLEYFTNKHASSKRWGRAINYTGWLTLDGNKYYFQSNSKAVTGLQKISDKYYYFNDNGQMQIKWQIINNNKYYFDGNTGEAIIGWFNNNKERYYFDSEGRLLTGYQVIGDKSYYFSDNINGNWEEGSGVLKSGIFKTPSGFKLFSSEGDKSAINYKGWLDLNGNKYYFNSDSIAVTGSYNIKGIQYYFNPKTAVLTNGWYTLDNNNYYVSNGHNVLGYQDIDGKGYYFDPSTGIQKAGVFPTPNGLRYFTMKPIDGQRWGQCIDYTGWLHLNGNKYYFGYYNSAVTGWRVLGGKRYFFNIKTGAATTGLLTLSGKRYYFNEKGEQLTLV
Catalytic domain sequence
375 aa
KNLSFIWIGGPISDQSLEYYNMWKMFNKDYNIRLFYDKNSLLVNTLKTAIIQESSKVIIEQNQSNILDGTYGHNKFYSDRMKLIYRYKRELKMLYENMKQNNSVDDIIINFLSNYFKYDIGKLNNQKENNNNKMIAIGATDINTENILTNKLKSYYYQELIQTNNLAAASDILRIAILKKYGGVYCDLDFLPGVNLSLFNDISKPNGMDSNYWEAAIFEAIANEKKLMNNYPYKYMEQVPSEIKERILSFVRNHDINDLILPLGDIKISQLEILLSRLKAATGKKTFSNAFIISNNDSLTLNNLISQLENRYEILNSIIQEKFKICETYDSYINSVSELVLETTPKNLSMDGSSFYQQIIGYLSSGFKPEVNSTV
